Clinical Trials Logo

Clinical Trial Summary

The aim of this present study is to investigate the use of benralizumab as treatment for severe nasal polyposis. The effect of benralizumab on nasal polyps will be assessed over a 56 weeks of treatment period in patients with severe bilateral nasal polyposis who are still symptomatic despite standard of care therapy, i.e current use of intranasal corticosteroids (INCS) and prior surgery and/or use of systemic corticosteroids. The first 200 patients that complete the 56-week treatment will have a 6 month follow-up (FU) period without dosing.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03401229
Study type Interventional
Source AstraZeneca
Contact
Status Completed
Phase Phase 3
Start date January 15, 2018
Completion date July 31, 2020

See also
  Status Clinical Trial Phase
Completed NCT04532736 - Comparison of Methylprednisolone or Methotrexate in the Maintenance Treatment of Nasal Polyposis Phase 2
Completed NCT02784262 - Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis Phase 2
Active, not recruiting NCT04157335 - Efficacy and Safety Study of Benralizumab in Patient With Eosinophilic Chronic Rhinosinusitis With Nasal Polyps (ORCHID) Phase 3
Completed NCT02562924 - The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery N/A
Completed NCT00480298 - Double-Blind Randomized Placebo-Controlled Trial on Clinical and Biological Effects of Oral Corticosteroids or Doxycyclin in Patients With Nasal Polyposis Phase 2
Completed NCT03358329 - Safety Evaluation of Repeat Placement of the S8 Sinus Implant in Chronic Sinusitis Patients With Nasal Polyps (ENCORE) Phase 3
Active, not recruiting NCT01906697 - The Effect of RF Turbinoplasty in Polypoid Change of Middle Turbinates Phase 3
Completed NCT03591068 - Efficacy & Safety of OPN-375 Adults With Bilateral Nasal Polyps Using Nasoendoscopic Video Phase 3
Recruiting NCT05056714 - Development of a Severity Assessment Score for Nasosinus Polyposis (PSI Score)
Recruiting NCT03979716 - Smell Exploration in Patients With Nasal Polyposis : Study by Functional Magnetic Resonance Imaging N/A
Not yet recruiting NCT05131958 - Nasality Evolution in a Nasal Polyposis Context : Multiparametric Evaluation : Articulatory (Imaging), Aerodynamics, Acoustics and Perception
Completed NCT02291549 - S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps Phase 3
Completed NCT01393340 - Clinical and Biological Effects of Anti-IgE (Omalizumab) in Patients With Bilateral Nasal Polyposis and Asthma Phase 2
Completed NCT02734849 - Study to Evaluate Multiple Doses in Patients With Nasal Polyposis Phase 2