Clinical Trials Logo

Clinical Trial Summary

Narcolepsy Type 1 (NT1) is a rare chronic neurological disorder resulting from the selective loss of hypocretin neurons. Patients with NT1 suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy (emotionally triggered episodes of muscle atonia). The disease is associated with numerous comorbidities such as obesity, metabolic disorders, anxiety-depressive disorders, and attentional disorders, all of which have a strong impact on quality of life.


Clinical Trial Description

Narcolepsy Type 1 (NT1) is a rare chronic neurological disorder resulting from the selective loss of hypocretin neurons. Patients with NT1 suffer from excessive daytime sleepiness, disrupted nighttime sleep, and cataplexy (emotionally triggered episodes of muscle atonia). The disease is associated with numerous comorbidities such as obesity, metabolic disorders, anxiety-depressive disorders, and attentional disorders, all of which have a strong impact on quality of life. Current management is based on sleep hygiene as well as wake-promoting and anti-cataplectic medications. However, many patients complain of residual sleepiness or cataplexy. In addition, most of the proposed treatments are accompanied by side effects and have little effect on the comorbidities associated with the disease. Therapeutic alternatives are therefore needed in the management of narcolepsy. Regular Physical Activity (RPA) is recommended by the World Health Organization (WHO) and has been shown to improve anxiety disorders, obesity, metabolic disorders, cognitive functions, sleep and quality of life. In NT1, patients have fewer opportunities to practice RPA because of daytime sleepiness as well as increased sleep needs. Some studies suggest that cardiorespiratory performances may be lower in NT1 patients than in healthy controls, and that a higher level of physical activity may be associated with lower sleepiness and better metabolic profile in NT1 children. However, no prospective study has evaluated the feasibility of an exercise training program in NT1 or the effect of regular physical activity on disease severity. The main objective of the study is to evaluate the effect of a physical activity training program of 3 sessions per week for 6 weeks on the severity of narcolepsy in sedentary adults with NT1. The secondary objectives are to evaluate the feasibility of this program in an adult NT1 population, the effect of the program on comorbidities (obesity, metabolic disorders, anxiety-depressive symptoms, cognitive disorders), medication dosage and quality of life, its tolerance, and the satisfaction of the patients at short- (6 weeks) and long-term (6 months). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05460052
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Completed
Phase
Start date August 26, 2022
Completion date November 24, 2023

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05983731 - A Pilot Observational Study to Assess the Ability of Continuous 'Home' EEG to Accurately Diagnose Narcolepsy and Demonstrate Response to Treatment
Suspended NCT04419792 - 'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy'
Completed NCT05375890 - Clinical and Neurophysiological Characteristics of Narcolepsy
Not yet recruiting NCT06292598 - Bacterial Translocation and Gut Microbiota in Type 1 Narcolepsy Patients Versus a Control Population
Recruiting NCT06358950 - A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201) Phase 2
Not yet recruiting NCT06457945 - Mind-wandering and Predictive Processes in Narcolepsy: a Putative Mechanism Through Covert REM Intrusions N/A
Not yet recruiting NCT06383806 - Decreasing Nightmares in Adults With Narcolepsy N/A
Not yet recruiting NCT05914194 - A Eight-Week Study of NLS-2 (Mazindol Extended Release) in Participants With Narcolepsy Type 1 Phase 3
Completed NCT05687903 - A Study of TAK-861 in Participants With Narcolepsy Type 1 Phase 2
Recruiting NCT05967832 - Contribution of 7 Tesla MRI of the Hypothalamus in the Diagnosis of Type 1 Narcolepsy N/A
Completed NCT05709873 - Narcolepsy Nightmare Study N/A
Recruiting NCT04483310 - Meditation-Relaxation (MR Therapy) for Sleep Paralysis. N/A
Completed NCT04445129 - Wake and Sleep State Transitions on a Portable Electroencephalogram (EEG) Device in Narcolepsy Type 1 (NT1) and Healthy Participants
Completed NCT05314556 - Group Psychotherapy in Narcolepsy Type 1 N/A
Recruiting NCT05816382 - A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions Phase 2/Phase 3
Recruiting NCT06336057 - Mentalizating in Adults Suffering From Narcolepsy Type 1.
Recruiting NCT06251063 - Improving Social Relationships for Adolescents With Central Disorders of Hypersomnolence N/A
Completed NCT06241911 - Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Narcolepsy Type 1 N/A