Narcolepsy Type 1 (NT1) Clinical Trial
Official title:
A Randomized, Double-Blind, Single-Dose, 5-Period Crossover Study to Evaluate the Efficacy, Safety, and Tolerability of E2086 Compared to Placebo and Active Comparator in Adult Subjects With Narcolepsy Type 1
The primary purpose of this study is to evaluate the efficacy of single oral doses of E2086 compared to placebo in the treatment of excessive daytime sleepiness (EDS) as assessed by the Maintenance of Wakefulness Test (MWT) in adult participants with narcolepsy type 1 (NT1).
| Status | Not yet recruiting |
| Enrollment | 40 |
| Est. completion date | February 14, 2025 |
| Est. primary completion date | February 14, 2025 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: 1. Male or female, age greater than or equal to (>=) 18 years at the time of informed consent 2. Diagnosis of NT1 defined by the following criteria: - History of daily periods of the irrepressible need to sleep, or daytime lapses into sleep, occurring for at least 3 months - History of cataplexy (which must be confirmed during the Screening Period by Sleep/Cataplexy Diary) - At least one of the following: - On Screening multiple sleep latency test (MSLT): MSL of less than or equal to (<=) 8 minutes and 2 or more sleep onset rapid eye movement periods (SOREMPs) on an MSLT performed according to standard techniques - On Screening nocturnal polysomnography (PSG): One or more SOREMPs within 15 minutes of sleep onset 3. Epworth Sleepiness Scale score >=10 4. Reports regular bedtime, defined as the time that the participant attempts to sleep, between 22:00 and midnight (based on data from the Screening Sleep/Cataplexy Diary) 5. Reports regular waketime, defined at the time the participant gets out of bed for the day, between 05:00 and 10:00 (based on data from the Screening Sleep/Cataplexy Diary) 6. Reports being in bed between 7 and 9 hours per night (based on data from the Screening Sleep/Cataplexy Diary) 7. Body mass index (BMI) >=18 to less than (<) 40 kilograms per meter square (kg/m^2), at Screening Exclusion Criteria 1. Females who are breastfeeding or pregnant at Screening or Baseline (as documented by a positive beta-human chorionic gonadotropin [ß-hCG] or human chorionic gonadotropin [hCG] test with a minimum sensitivity of 25 international units per liter (IU/L) or equivalent units of ß-hCG [or hCG]), and females who are breastfeeding or pregnant during the Treatment Period. A separate baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the 1st dose of study drug 2. Females of childbearing potential who: - Within 28 days before study entry, did not use a highly effective method of contraception, which includes any of the following: - total abstinence (if it is their preferred and usual lifestyle) - a nonhormonal intrauterine device (example, "coil") or a progesterone-only intrauterine hormone-releasing system - a nonsteroidal oral contraceptive (participant must have been on a stable dose of the same nonsteroidal oral contraceptive product for at least 28 days before dosing and must agree to stay on the same dose of the oral contraceptive throughout the study and for 28 days after study drug discontinuation.) - depot medroxyprogesterone acetate or depot norethisterone enantate. - have a vasectomized partner with confirmed azoospermia. - Do not agree to use a highly effective method of contraception (as described above) throughout the entire study period and for 30 days after study drug administration. - Participants on an oral contraceptive must use an additional barrier method throughout the study and for 30 days after study drug administration. NOTE: All females will be considered to be of childbearing potential unless they are postmenopausal (amenorrheic for at least 12 consecutive months, in the appropriate age group, and without other known or suspected cause) or have been sterilized surgically (that are, bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing). 3. Males who have not had a successful vasectomy (confirmed azoospermia) if their female partners meet the exclusion criteria above that is, the female partners are of childbearing potential and are not willing to use a highly effective contraceptive method throughout the study period and for 92 days after study drug administration. No sperm donation is allowed during the study period and for 95 days after study drug administration 4. History of myocardial infarction, ischemic heart disease, or cardiac failure at Screening 5. History of clinically significant arrhythmia or uncontrolled arrhythmia 6. Known to have or probable positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 14 days of any study visit. 7. Exposure within the last 10 days to an individual with confirmed or probable coronavirus disease-2019 (COVID-19) or symptoms within the last 10 days that are on the most recent Centers for Disease Control and Prevention (CDC) list of COVID symptoms 8. Hypersensitivity to excipients of the study drug (E2086), or to active comparator or any of its excipients 9. Any suicidal ideation with intent with or without a plan at Screening or within 6 months of Screening (that is, answering "Yes" to questions 4 or 5 on the Suicidal Ideation section of the CSSRS) 10. Any lifetime suicidal behavior (per the Suicidal Behavior section of the C-SSRS) 11. Any history of psychiatric disease (including but not limited to depression or other mood disorders, bipolar disorder, psychotic disorders, including schizophrenia, panic attacks, anxiety disorders), within 10 years of Screening 12. Any current psychiatric symptoms as indicated by a standard screening tool (Diagnostic and Statistical Manual of Mental Disorders [DSM-5] Self-Rated Level 1 Cross-Cutting Symptom Measure - Adult) 13. Participants with one or more 1st degree (blood) relatives who have lifetime diagnosis of bipolar type I disorder or a psychotic disorder 14. Psychotic disorder(s) or unstable recurrent affective disorder(s) evident by use of antipsychotics within 2 years before Screening 15. Evidence of clinically significant disease (examples, allergies; cardiac, respiratory, gastrointestinal, renal disease) that in the opinion of the investigator(s) could affect the participant's safety or interfere with the study assessments. 16. Any clinically abnormal symptom or organ impairment found by medical history, physical examinations, vital signs, ECG finding, or laboratory test results that require medical treatment at Screening or Baseline 17. Any history of or concomitant medical condition that in the opinion of the investigator(s) would compromise the participant's ability to safely complete the study. 18. History of drug or alcohol dependency or abuse within 2 years before Screening 19. Use of illegal recreational drugs at Screening and throughout the study 20. Intake of herbal preparations containing St. John's Wort within 4 weeks before dosing 21. Currently enrolled in another clinical study or used any investigational drug or device within 28 days or 5* the half-life, (whichever is longer) preceding informed consent. 22. Evidence of disease that may influence the outcome of the study within 4 weeks before dosing (examples, psychiatric disorders and disorders of the gastrointestinal tract, liver, kidney, respiratory system, endocrine system, hematological system, neurological system, or cardiovascular system) 23. History of formally diagnosed moderate to severe obstructive sleep apnea, current use of continuous positive airway pressure, or symptomatic restless legs syndrome 24. Apnea-hypopnea index >=15 on Screening PSG 25. Periodic limb movement arousal index (PLMAI)>=15 on Screening PSG 26. Use of anti-cataplectic medications within 5* the half-life before Screening 27. Use of psychostimulant medications, prescription and over-the-counter (OTC), within 5*the half-life before Screening - Examples of prohibited medications include OTC stimulants (example, pseudoephedrine), methylphenidate, amphetamines, modafinil, armodafinil, sodium oxybate, and pemoline 28. Use of sleep promoting medications, prescription and OTC, within 28 days or 5*the half-life before Screening - Examples of prohibited medication include OTC sleep aids, trazodone, hypnotics, benzodiazepines, barbiturates, cannabinoids, and opioids. |
| Country | Name | City | State |
|---|---|---|---|
| n/a | |||
| Lead Sponsor | Collaborator |
|---|---|
| Eisai Inc. |
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Mean Sleep Latency (MSL) as Assessed by the 4 Maintenance of Wakefulness Tests (MWTs) for E2086 Versus Placebo at Day 1 | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of excessive daytime sleepiness (EDS) which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | At Day 1 | |
| Primary | MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 5 | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of EDS which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | At Day 5 | |
| Primary | MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 9 | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of EDS which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | At Day 9 | |
| Primary | MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 13 | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of EDS which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | At Day 13 | |
| Primary | MSL as Assessed by the 4 MWTs for E2086 Versus Placebo at Day 17 | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of EDS which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | At Day 17 | |
| Secondary | MSL as Assessed by the 4 MWTs for E2086 Versus Active Comparator | Sleep latency is defined as the amount of time a person takes to fall asleep. The MWT is an objective assessment of EDS which consists of measurement tests. A participant undergoes four 40-minute wake trials, where an increased ability to stay awake in the context of trying to remain awake is reflected in a prolonged sleep latency. These measurements of sleep latency at regular intervals across the day are averaged to calculate the mean sleep latency. The MWT will be performed as per the 2021 guidance of the American Academy of Sleep Medicine. | Days 1, 5, 9, 13 and 17 | |
| Secondary | Karolinska Sleepiness Scale (KSS) Score for E2086 Versus Active Comparator | The KSS is a subjective measure of an individual's level of sleepiness during the last 10 minutes, as assessed at a particular time of day. The KSS is rated on a 10-point scale, from 1 = extremely alert, to 10 = extremely sleepy, falls asleep all the time. Higher score indicates more sleepiness. | Day 1 up to Day 18 | |
| Secondary | KSS Score for E2086 Versus Placebo | The KSS is a subjective measure of an individual's level of sleepiness during the last 10 minutes, as assessed at a particular time of day. The KSS is rated on a 10-point scale, from 1 = extremely alert, to 10 = extremely sleepy, falls asleep all the time. Higher score indicates more sleepiness. | Day 1 up to Day 18 | |
| Secondary | Number of Participants With Treatment-emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs) | From first dose of study drug up to Day 20 | ||
| Secondary | Number of Participants With Markedly Abnormal Clinical Laboratory Values | Clinical laboratory will include hematology, chemistry, and urinalysis. | Baseline up to Day 20 | |
| Secondary | Number of Participants With Markedly Abnormal Vital Sign Values | Vital sign parameters will include systolic and diastolic blood pressure, pulse, respiratory rate, body temperature. | Baseline up to Day 20 | |
| Secondary | Number of Participants With Markedly Abnormal Electrocardiogram (ECGs) Findings | Baseline up to Day 20 | ||
| Secondary | Number of Participants With Markedly Abnormal Electroencephalogram (EEGs) Findings | Baseline up to Day 20 | ||
| Secondary | Number of Participants With Suicidality as Assessed by Columbia - Suicide Severity Rating Scale (C-SSRS) | Suicidality will be assessed using the C-SSRS. The C-SSRS assesses an individual's degree of suicidality, including suicidal ideation and suicidal behavior. The C-SSRS is an interview-based rating scale to systematically assess any suicidality, suicidal behavior, or suicidal ideation. Any suicidality is emergence of any suicidal ideation or suicidal behavior. Any suicidal behavior is indicated when response is "yes" for any these questions- actual attempt to suicide, engaged in non-suicidal self-injurious behavior, interrupted attempt, aborted attempt, preparatory acts. Any suicidal ideation is indicated when response is "yes" for any of these questions- wish to be dead, non-specific active suicidal thoughts, active suicidal ideation with methods without intent to act or some intent to act, without specific plan or with specific plan and intent to suicide. | Baseline up to Day 20 | |
| Secondary | Cmax: Maximum Observed Plasma Concentration of E2086 and its Metabolite M1 | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose | ||
| Secondary | Tmax: Time to Reach Cmax of E2086 and its Metabolite M1 | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose | ||
| Secondary | AUC(0-t): Area Under the Plasma Concentration-time Curve From Zero Time to Time of Last Quantifiable Concentration of E2086 and its Metabolite M1 | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose | ||
| Secondary | AUC(0-inf): Area Under the Plasma Concentration-time Curve From Zero Time Extrapolated to Infinite of E2086 and its Metabolite M1 | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose | ||
| Secondary | t½: Terminal Phase Half-life of E2086 and its Metabolite M1 | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose | ||
| Secondary | MRp: Metabolite Ratio of AUC(0-inf) | MRp will be calculated as ratio of plasma AUC(0-inf) of metabolite to parent following molar correction. | Days 1, 5, 9, 13 and 17: 0-24 hours post-dose |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
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