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NASH AMPK Exercise Dosing (AMPED) Trial — AMPED  

NAFLD Clinical Trial

Official title:
NASH AMPK Exercise Dosing (AMPED) Trial

Clinical Trial Summary

There is no known cure or regulatory agency approved drug therapy for nonalcoholic fatty liver disease (NAFLD), the leading cause of liver disease worldwide, and its progressive type, NASH. This places increased importance on using exercise to treat NAFLD. While physical activity is recommended for all with NAFLD, how to best prescribe exercise as a specific treatment remains unknown, including what dose of exercise is most effective.

Clinical Trial Description

The mechanism explaining how exercise training benefits patients with NAFLD and NASH is unclear. The AMPK pathway may be responsible for the benefits seen with exercise training because: 1) AMPK has a liver-specific role in hepatic de novo lipogenesis and fatty acid oxidation, 2) AMPK activity is abnormally low in NAFLD and 3) NAFLD animal models demonstrate exercise changes the liver-specific AMPK pathway, leading to less liver fat accumulation by reducing lipogenesis and increasing fatty acid oxidation (This has not been studied in patients). Importantly, exercise-induced AMPK activation appears to be dose dependent. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04987879
Study type Interventional
Source Milton S. Hershey Medical Center
Contact Breianna L Hummer, MS
Phone 7175310003
Email bhummer@pennstatehealth.psu.edu
Status Recruiting
Phase N/A
Start date August 30, 2022
Completion date June 1, 2026
View Details
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