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NCT04561895 Clinical Trial

Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients

NAFLD Clinical Trial

Official title:
Genetic Variations in Adipokine to Improve Risk Prediction for NAFLD and Its Progression to NASH in Egyptian Patients

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04561895
Other study ID # LC ElSahel
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2020
Est. completion date September 16, 2020

Study information
Verified date September 2020
Source Cairo University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also to find different related factors including obesitu, diabetes and liver enzymes level

Recruitment information / eligibility
Status Completed
Enrollment 224
Est. completion date September 16, 2020
Est. primary completion date September 15, 2020
Accepts healthy volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

Egyptian patients confirmed NAFLD diagnosis diabetic

-

Exclusion Criteria:

- Pregnancy and lactation, history of alcohol abuse (as defined by an average daily consumption of alcohol > 30 g/day in men and > 20 g/day women), cirrhosis, autoimmune hepatitis and other causes of liver disease (viral hepatitis, hemochromatosis, Wilson's disease), drug induced hepatitis, chronic enteropathies, Chronic kidney disease

Study Design

Related Conditions & MeSH terms

  • Fatty Liver
  • NAFLD
  • NASH - Nonalcoholic Steatohepatitis
  • Non-alcoholic Fatty Liver Disease

Intervention

Genetic:
• DNA extraction
investigation of DNA polymorphism in patients suffering from NAFLD

Locations
Country Name City State
Egypt El Sahel teaching hospital Cairo Shobra

Sponsors (2)
Lead Sponsor Collaborator
Cairo University Elsahel teaching hospital

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary investigate adipokine dna polymorphism to investigate adipokine gene polymorphism associated with prognosis of NAFLD patients 1 months
Primary correlations to correlate between gene polymorphism and glycated hemoglobin, liver enzyme and obesity 1 month
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