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NCT02083159 Clinical Trial

C1q/TNF-related Proteins in Non-Alcoholic Fatty Liver Disease

NAFLD Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02083159
Other study ID # NAFLD(CTRP)
Secondary ID
Status Recruiting
Phase N/A
First received March 7, 2014
Last updated September 19, 2016
Start date March 2012

Study information
Verified date September 2016
Source Korea University
Contact Ho Cheol Hong, M.D.
Phone 822-2626-3044
Email naeyo21@naver.com
Is FDA regulated No
Health authority South Korea: Institutional Review Board
Study type Observational

Clinical Trial Summary

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn`t been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy.

Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation.

The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.

Recruitment information / eligibility
Status Recruiting
Enrollment 500
Est. completion date
Est. primary completion date December 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 20 Years to 80 Years
Eligibility Inclusion Criteria:

- 20<age<80

- apparently healthy subjects

Exclusion Criteria:

- a history of CVD

- diabetes

- stage 2 hypertension

- malignancy

- severe renal or hepatic disease

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

  • NAFLD
  • Non-alcoholic Fatty Liver Disease

Locations
Country Name City State
Korea, Republic of Korea Univ. Guro Hospital Seoul

Sponsors (1)
Lead Sponsor Collaborator
Korea University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD at enrollment No
Secondary The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles at enrollment No
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