Myositis Clinical Trial
Official title:
Comparison of Magnetic Resonance (MR) Imaging Against Clinical Criteria in the Diagnosis and Monitoring of Adult Idiopathic Myopathy
A prospective observational study to determine the effectiveness of magnetic resonance (MR) imaging in the diagnosis and monitoring of idiopathic myopathy in adult humans.
Idiopathic inflammatory myopathies are a heterogeneous group of conditions characterised by
skeletal muscle inflammation leading to proximal muscle weakness, often with tenderness, and
occasionally dermatological manifestations. Diagnosis is clinical and is based on the Bohan
and Peter criteria which comprises clinical examination, serological markers,
electromyography (EMG) and muscle biopsy. This has relatively poor sensitivity and
specificity. Muscle biopsy in particular has a false negative rate of 10-15% and is
invasive. Clinical criteria also lack the discriminatory power to differentiate between
recurrent (or breakthrough) myopathy and myopathy secondary to treatment with
corticosteroid.
Magnetic resonance (MR) imaging has the advantage of being non-invasive, and is able to
discriminate between different tissues, and to identify areas of inflammation. The aim of
this study is to assess the effectiveness of MR sequences in the diagnosis of myopathy,
monitoring of treatment response, and in differentiating between breakthrough myopathy and
steroid-induced myopathy.
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Time Perspective: Prospective
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