Myopia Clinical Trial
Official title:
Comparison of Early Changes in Ocular Surface and Inflammatory Mediators Between Lenticule Extraction and Femtosecond Laser-assisted Laser in Situ Keratomileusis
The aim is to evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after lenticule extraction (FLEx) and femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) procedures.
Over the past few years, laser in situ keratomileusis with a femtosecond laser-created flap
(FS-LASIK)has been a popular ophthalmic procedure for the correction of refractive error.
This first all-in-one FS-laser system was designed to perform the refractive lenticule
extraction (ReLEx) procedures, femtosecond lenticule extraction (FLEx).They have the same
feature: corneal flap.
Ocular surface disruption during corneal refractive surgery is commonly considered to be
closely related to the development of dry eye. Multiple etiologies contribute to this ocular
surface disruption, including the flap creation and stromal ablation involved in previous
refractive surgery techniques. Corneal nerve damage has been considered the main cause of
dry eye, due to disrupted afferent sensory nerves, reduced blink reflex, and increased tear
evaporation leading to tear film instability. In addition, postoperative inflammatory
mediator fluctuations are also a key factor related to ocular surface damage. Extensive
research has described the effects of cytokines, chemokines and growth factors in modulating
corneal wound healing, cell migration, and apoptosis on the ocular surface after refractive
surgery.
This prospective clinical study is going to assess the short-term changes in ocular surface
measures and tear inflammatory mediators after lenticule extraction (FLEx) and femtosecond
laser-assisted laser in situ keratomileusis (FS-LASIK) procedures.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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