Clinical Trial Details
— Status: Recruiting
Administrative data
NCT number |
NCT05599568 |
Other study ID # |
P-2022-168 |
Secondary ID |
|
Status |
Recruiting |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
May 15, 2022 |
Est. completion date |
May 30, 2025 |
Study information
Verified date |
April 2024 |
Source |
Rigshospitalet, Denmark |
Contact |
Mads Stemmerik, MD |
Phone |
+4535456126 |
Email |
mads.peter.godtfeldt.stemmerik[@]regionh.dk |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
The repeated bout effect (RBE) refers to the adaptation whereby a single bout of eccentric
exercise protects against muscle damage from subsequent eccentric bouts. This effect has been
shown in many muscle groups using both serum biomarkers, muscle soreness and imaging
techniques. Though the effect is well described in healthy, it has never been studied in
patients with neuromuscular diseases (NMDs).
In healthy, the RBE is only described using eccentric exercise, but unlike healthy persons,
patients with NMDs can experience significant muscle damage with concentric exercise. This
raises the question, if patients with NMDs could also show RBE when performing concentric
exercise.
Description:
The repeated bout effect (RBE) refers to the adaptation whereby a single bout of eccentric
exercise protects against muscle damage from subsequent eccentric bouts. This effect has been
shown in many muscle groups using both serum biomarkers, muscle soreness and imaging
techniques. Though the effect is well described in healthy, it has never been studied in
patients with neuromuscular diseases (NMDs).
NMDs are a common term for diseases that affect the muscles by disease processes in the motor
neuron, peripheral nerve, neuromuscular junction or the muscles. The diseases can cause
symptoms such as muscle weakness, muscle fatigue and sometimes muscle pain and varying
degrees of physical disability. As the mechanisms for disease varies among NMDs, it is likely
that some patients will experience RBE in a similar fashion to healthy, while others may not.
Recent years have shown significant breakthrough in the treatment development for various
NMDs, and many of these treatments are currently or will soon be evaluated in clinical
trials. As many trials will use exercise to evaluate treatment effect, it is vital to
understand whether a single bout of exercise in itself provides a protective effect on the
muscles of patients with NMDs.
In healthy, the RBE is only described using eccentric exercise, but unlike healthy persons,
patients with NMDs can experience significant muscle damage with concentric exercise. This
raises the question, if patients with NMDs could also show RBE when performing concentric
exercise.