Myopathy (Statin Associated) Clinical Trial
Official title:
Metabolic Features of Post-Myopathy Patients Associated With Statin Treatment
Statins are a class of drugs given to lower cholesterol. Although statins are considered to
be generally safe, some studies show that about 10% of people on statins develop
muscle-related symptoms, from fatigue (tiredness), weakness, cramping, pain and sometimes a
lifethreatening muscle breakdown condition known as rhabdomyolysis. In some, these symptoms
may greatly affect their daily activities. One consideration why symptoms develop in only
some patients is that they may have an underlying problem in the way their muscles use fats
to produce energy. In these patients, the muscles are not able to fully utilize fats and so
they become tired more easily. Fat within the muscle can also affect how your body uses a
hormone called insulin, which affects your blood sugar levels. The investigators are
specifically interested in previous statin users and determine if the muscle symptoms are
related to changes in energy and sugar use. We propose to enroll patients who have developed
muscle side effects on previous statin treatment and have since discontinued statin
treatment.
Our aim is to compare the metabolic parameters in these patients to age and gender-matched
normal individuals.
n/a
Observational Model: Cohort, Time Perspective: Prospective