Fostamatinib as a Single Agent or in Combination With Ruxolitinib for

Clinical Trial Summary

Fostamatinib may improve thrombocytopenia in myelofibrosis patients with severe thrombocytopenia (platelet <50,000/microL) and allow them to initiate treatment with a JAK2 inhibitor, ruxolitinib. Additionally, fostamatinib monotherapy may also improve myelofibrosis related symptoms and splenomegaly.

See also
Status	Clinical Trial	Phase
Completed	`NCT02916979` - Myeloid-Derived Suppressor Cells and Checkpoint Immune Regulators' Expression in Allogeneic SCT Using FluBuATG	Phase 1
Not yet recruiting	`NCT06345495` - High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly	Phase 2
Terminated	`NCT04866056` - Jaktinib and Azacitidine In Treating Patients With MDS With MF or MDS/MPN With MF.	Phase 1/Phase 2
Completed	`NCT02784496` - Long-Term Side Effects of Ruxolitinib in Treating Patients With Myelofibrosis	Phase 2
Completed	`NCT00069680` - Genetic Analysis of Gray Platelet Syndrome
Active, not recruiting	`NCT04097821` - Platform Study of Novel Ruxolitinib Combinations in Myelofibrosis Patients	Phase 1/Phase 2
Active, not recruiting	`NCT03289910` - Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia	Phase 2
Completed	`NCT04666025` - SARS-CoV-2 Donor-Recipient Immunity Transfer
Not yet recruiting	`NCT06397313` - RVU120 in Patients With Intermediate or High-risk, Primary or Secondary Myelofibrosis	Phase 2
Not yet recruiting	`NCT06024915` - A Study to Evaluate Drug-Drug Interaction of TQ05105 Tablets	Phase 1
Terminated	`NCT02877082` - Tacrolimus, Bortezomib, & Thymoglobulin in Preventing Low Toxicity GVHD in Donor Blood Stem Cell Transplant Patients	Phase 2
Completed	`NCT02910258` - Interferon-pegyle α2a Efficiency and Tolerance in Myelofibrosis
Completed	`NCT00975975` - Basiliximab #2: In-Vivo Activated T-Cell Depletion to Prevent Graft-Versus_Host Disease (GVHD) After Nonmyeloablative Allotransplantation for the Treatment of Blood Cancer	Phase 2
Completed	`NCT00997386` - Reduced Intensity Allogeneic PBSCT to Treat Hematologic Malignancies and Hematopoietic Failure States	Phase 2
Completed	`NCT00666549` - Research Tissue Bank
Terminated	`NCT00522990` - Study to Assess the Safety of Escalating Doses of AT9283, in Patients With Leukemias	Phase 1/Phase 2
Terminated	`NCT00393380` - Study of Parathyroid Hormone Following Sequential Cord Blood Transplantation From an Unrelated Donor	Phase 2
Completed	`NCT00606437` - Total Body Irradiation With Fludarabine Followed by Combined Umbilical Cord Blood (UCB) Transplants	Phase 1
Active, not recruiting	`NCT03952039` - An Efficacy and Safety Study of Fedratinib Compared to Best Available Therapy in Subjects With DIPSS-intermediate or High-risk Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, or Post-essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib	Phase 3
Not yet recruiting	`NCT04709458` - Safety and Early Efficacy Study of TBX-2400 in Patients With AML or Myelofibrosis	Phase 1

NCT number	NCT04543279
Study type	Interventional
Source	Washington University School of Medicine
Contact
Status	Terminated
Phase	Phase 2
Start date	May 3, 2021
Completion date	July 30, 2022

Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms