A Study of Oral TP-3654 in Patients With Myelofibrosis

Status Recruiting

Clinical Trial Summary

This study is a Phase 1/2, multicenter, dose-escalation, open-label trial to assess safety, tolerability, pharmacokinetics and pharmacodynamics of TP-3654 in patients with intermediate or high-risk primary or secondary MF.

Clinical Trial Description

Arm 1 will enroll patients who have been previously treated and failed on a JAK inhibitor or ineligible to receive ruxolitinib or fedratinib. Arm 2 will enroll patients who are on a stable dose of ruxolitinib, but who have either lost response or had a suboptimal or plateau in response. Arm 3 will enroll patients who have been previously treated on JAK inhibitor (except momelotinib) that was complicated by anemia, thrombocytopenia or hematoma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04176198
Study type	Interventional
Source	Sumitomo Pharma America, Inc.
Contact	Reyna Bishop
Phone	617-674-6800
Email	reyna.bishop@us.sumitomo-pharma.com
Status	Recruiting
Phase	Phase 1/Phase 2
Start date	December 16, 2019
Completion date	April 30, 2030

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