Myelofibrosis Clinical Trial
Official title:
A Phase 1b Open-Label Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Idelalisib in Subjects Receiving Ruxolitinib as Therapy for Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis With Progressive or Relapsed Disease
The primary objective of this study is to evaluate the safety, tolerability, and
pharmacokinetics of idelalisib in adults receiving ruxolitinib as therapy for intermediate to
high-risk primary myelofibrosis (PMF), post-polycythemia vera, or post-essential
thrombocythemia myelofibrosis (post-PV MF or post-ET MF) with progressive or relapsed
disease.
This is a dose-escalation study. There will be 4 cohorts (A, B, C, D). Participants will
receive an escalating dose or dose frequency of idelalisib based on the safety data of
available cohort(s).
n/a
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