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Clinical Trial Summary

The primary objective of this study is to evaluate the safety, tolerability, and pharmacokinetics of idelalisib in adults receiving ruxolitinib as therapy for intermediate to high-risk primary myelofibrosis (PMF), post-polycythemia vera, or post-essential thrombocythemia myelofibrosis (post-PV MF or post-ET MF) with progressive or relapsed disease.

This is a dose-escalation study. There will be 4 cohorts (A, B, C, D). Participants will receive an escalating dose or dose frequency of idelalisib based on the safety data of available cohort(s).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02436135
Study type Interventional
Source Gilead Sciences
Contact
Status Terminated
Phase Phase 1
Start date June 5, 2015
Completion date November 20, 2017

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