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Mutism clinical trials

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NCT ID: NCT02300766 Recruiting - Clinical trials for Infratentorial Neoplasms

Cerebellar Mutism Syndrome Study

Start date: October 2014
Phase:
Study type: Observational [Patient Registry]

The purpose of this study is to determine why up to 25% of the pediatric patients who have surgery for a tumor in the posterior fossa develops the Cerebellar Mutism Syndrome (CMS). Furthermore the purpose is to explore the clinical course and the best treatment of the syndrome.

NCT ID: NCT02051192 Completed - Clinical trials for Obsessive-compulsive Disorder

Brief Behavioral Treatment for Anxiety in Young Children

PLET
Start date: January 2014
Phase: Phase 1/Phase 2
Study type: Interventional

Behaviorally and cognitive-behaviorally based therapeutic techniques (BT; CBT) that incorporate exposure therapy useful for treatment of anxiety disorders among typically developing children. Although a large amount of data demonstrate the effectiveness of of BT and CBT approaches for treating anxious youth, there is a gap in the literature for the effectiveness of these approaches for children under the age of seven. Evidence increasingly suggests that family factors such as accommodation and parenting style contribute significantly to the presence of anxiety symptoms as well as treatment outcomes, particularly in young children. These findings stress the importance of using a treatment approach in which parents are directly involved in education, parent training, and generalization of treatment effects. Therefore, this study aims to evaluate a new treatment program, parent-led behavioral treatment, for children ages 3 to 7 years of age who have a principal anxiety disorder diagnosis.

NCT ID: NCT02048176 Completed - Clinical trials for Posterior Fossa Mutism

Posterior Fossa Mutism on Quality of Life

Start date: July 2011
Phase: N/A
Study type: Observational

Posterior fossa mutism (PFM) occurs in up to 30% of patients after resection of a posterior fossa tumor, most commonly a medulloblastoma. PFM is characterized by delayed onset of mutism 1-6 days after surgery that can spontaneously improve on average from 7-8 weeks later. Few patients recover normal speech. Most of their speech continues to be marked by dysarthria, dysfluency and slowed rate. Researchers have not identified the pathophysiologic mechanism for PFM nor have they found a cure. Despite the improvements in speech, patients with PFM have shown multiple areas of neurocognitive deficits 12 months after diagnosis. Few studies have looked at long term outcomes of patients affected by PFM. We propose to survey patients who developed PFM after resection of a medulloblastoma to determine long term effects of PFM on patient's quality of life.

NCT ID: NCT02009839 Completed - Selective Mutism Clinical Trials

Web-Based CBT Protocol for Treatment of Selective Mutism

Start date: July 2005
Phase: N/A
Study type: Interventional

The main aim of this study is to examine the effectiveness of a web-based CBT protocol (entitled Meeky Mouse) in the treatment of children with Selective Mutism in Singapore. The researchers hypothesized that the Meeky Mouse program would be associated with higher frequency of speaking behaviors, lower levels of anxiety, greater improvements in clinician-rated severity of mental illness, and higher clinician-rated improvement scores at post-treatment.

NCT ID: NCT01733173 Completed - Brain Mass Clinical Trials

Functional Imaging of Cerebellar Mutism Syndrome

Start date: November 2012
Phase:
Study type: Observational

The purpose of this study is to better understand why some children with cancer have difficulty speaking after brain surgery. Difficulty speaking may be due to known complications to the language centers in the brain. These language centers may be located in slightly different places in different people. This study will study which areas may be damaged.

NCT ID: NCT01002196 Completed - Selective Mutism Clinical Trials

Randomised Controlled Treatment Study of Selective Mutism

Start date: June 2009
Phase: Phase 2
Study type: Interventional

Selective mutism (SM) describes inhibited and withdrawn children who are persistently mute in central situations despite ability to talk. SM may cause great suffering and create problems, both socially and related to learning. SM is associated with social anxiety, neurodevelopmental delay and bilingualism. The prevalence is about .7-8 ‰. Adequate assessment and treatment of SM is seldom provided in the mental health services. SM is considered hard to treat, and randomised treatment studies are lacking. This study will examine the effect of a manual based treatment for SM. The treatment consists of home- and kindergarten /school based interventions including behaviour techniques and psychoeducation. Defocused communication is a general treatment principle. Comorbidity, including neurodevelopmental delay /disorder, and predictors of outcome, will be examined. A pilot study was conducted to ensure the feasibility of the planned effectiveness study. Seven children, aged 3-5 years were included. Six has started treatment, and all talked in the kinder garden within the first 3 months. The present study will have a randomised controlled design with 1. Manual based intervention for 6 months compared to 2. Waiting list controls (3 months), and then manual based intervention. The sample: Children aged 3-9 years consecutively referred to the school psychology- or the mental health services in Oslo and Eastern Norway. Expected N = 24 based on the pilot study, is a sufficient sample size to answer our primary research question. The treatment will be given by a therapist from the research group or by a local clinician under supervision. The study can add essential knowledge on treatment of SM and make effective treatment available to clinicians in the community.

NCT ID: NCT00554749 Completed - Selective Mutism Clinical Trials

What Treatment Works for Children With Selective Mutism?

Start date: November 2007
Phase: N/A
Study type: Interventional

The purpose of this pilot study is to explore the outcome of a manual based treatment for children with Selective Mutism

NCT ID: NCT00458198 Completed - Selective Mutism Clinical Trials

Integrated Behavioral Therapy for Treating Children With Selective Mutism

Start date: January 2006
Phase: N/A
Study type: Interventional

This study will determine the effectiveness of integrated behavior therapy in treating children with selective mutism.