Pilot Study of Cardiac MR in Patients With Muscular Dystrophy

Status Active, not recruiting

Clinical Trial Summary

Muscular Dystrophy can affect the skeletal muscles and also the heart and breathing muscles, causing significant morbidity and mortality. As patients are now living longer, treatment of muscular dystrophies involves drugs that help improve heart function. However, better types of heart imaging studies are needed to understand how these treatments work. Researchers want to improve heart imaging to identify earlier indicators of heart dysfunction in muscular dystrophy patients and how these are changed by medical treatment. The new imaging indicators will also help identify candidates for entry into future clinical trials.

Clinical Trial Description

Cardiomyopathy causes significant morbidity and mortality in multiple forms of muscular dystrophy affecting children, including Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD) and subtypes of autosomal recessive limb-girdle muscular dystrophy (LGMD2). Pharmaceutical treatments for the cardiomyopathy of muscular dystrophy, including angiotensin-converting enzyme (ACE) inhibition and beta-adrenergic receptor blockade, afford significant benefit and demonstrate cardiac remodeling in clinical studies. Further studies are needed to identify and characterize more sensitive indicators of cardiac dysfunction in muscular dystrophy subjects to better stratify subjects for entry into clinical protocols. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02921321
Study type	Observational
Source	Children's National Research Institute
Contact
Status	Active, not recruiting
Phase
Start date	January 2014
Completion date	December 2024

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT04976972` - A Comparison of Patients Receiving a Total Knee Replacement With Robotic Assistance or With Conventional Instrumentation	N/A
Recruiting	`NCT05546541` - Epidemiology and Nutrition
Completed	`NCT05071469` - Comparison of Two Different Treatment Methods	N/A
Completed	`NCT05041400` - Distribution of Knee Isokinetic Angle-specific Moments and Ratios	N/A
Not yet recruiting	`NCT06216028` - Bone Marrow Aspirate Concentrate (BMAC) Treatment for Knee Osteoarthritis	Phase 3
Not yet recruiting	`NCT04932993` - Writing Down Goals	N/A
Completed	`NCT02944448` - A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip or Knee	Phase 2
Completed	`NCT02257489` - Phase 1 Study of ACE-083 in Healthy Subjects	Phase 1
Completed	`NCT02256098` - RSA RCT: ATTUNE™ TKA Versus PFC Sigma TKA	N/A
Completed	`NCT02269254` - Persona Versus NexGen	N/A
Completed	`NCT01979731` - Effects Job Rotation in the Prevention of Work Related Musculoskeletal Disorders	N/A
Active, not recruiting	`NCT01440153` - Additional Exercise Program in Professional Dancers	N/A
Completed	`NCT00968266` - Improving Beliefs About Medication in Patients With Rheumatoid Arthritis	N/A
Completed	`NCT05222126` - Efficacy of Ultrasound-Guided Hydrodissection in Carpal Tunnel Syndrome	N/A
Completed	`NCT05062694` - Physical Therapy Management Of The Patient With Central Sensitization
Recruiting	`NCT05564182` - High Intensity Laser Therapy in the Treatment of Hemiplegic Shoulder Pain	N/A
Completed	`NCT04009369` - Impacts of Physiotherapy Services in a Quebec Emergency Department	N/A
Completed	`NCT05561452` - The Efficacy of PRP Injection in the Treatment of Rotator Cuff Syndrome	N/A
Recruiting	`NCT05432609` - Standardization and Reproducibility Regarding Scanning Procedures and Measurements of Weight-bearing Cone Beam CT in the Lower Extremity
Completed	`NCT04959162` - The Effect of Theoretical Knowledge on Resident's Practical Performance in Musculoskeletal Ultrasound	N/A