Study of Morphology & Functional Magnetic Resonance Imaging (MRI) Muscle

Status Completed

Clinical Trial Summary

The safety of guided practice of physical activity in myopathies is increasingly accepted, including muscular dystrophies. In facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophy, the aerobic training showed its physiological and functional efficiency without affecting the quality of life of patients. The issue of exercise therapy extended to all neuromuscular diseases, as has been rigorously analyzed, shows that the use of a training program combining endurance exercise targeted exercises and strength is even more relevant.

To complete the multidimensional assessments be managed by each team ( physiological assessments, functional tissue and quality of life) it is relevant to continue , for a descriptive study quantitative and qualitative analyzes by muscle imaging and spectroscopy (MRI and Nuclear Resonance Imaging (NMR) spectroscopy ).

Clinical Trial Description

These non-invasive assessments already in place at the time of the initial training (FSHD1 study, NCT01116570) will be repeated in the medium (12 months) and long term (30 months) in the same laboratory NMR AIM - CEA , Institute of Myology in Paris (P Carlier ). The data obtained from NMR repeated examinations and those obtained from biochemical analyzes and additional muscle histomorphometric (cellular aging estimation of involution fibroadipose ) on biopsies already programmed (initial, 6 months and 30 months, FSHD2 study, NCT01689480) will be respectively compared to initial time to follow the evolution food and energy capacity of trained muscles. The study of biopsies provide mechanistic arguments and morphometric specific cellular response to exercise, data will be advantageously complemented by NMR specialized examinations extended to all the muscles of the thigh (target of training ) and muscle quantification whole body MRI. ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01990976
Study type	Observational
Source	Centre Hospitalier Universitaire de Saint Etienne
Contact
Status	Completed
Phase	N/A
Start date	May 2012
Completion date	June 2015

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT01834040` - Study Safety and Efficacy of BMMNC for the Patient With Duchenne Muscular Dystrophy	Phase 1/Phase 2
Recruiting	`NCT01834066` - Study Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Muscular Dystrophy.	Phase 1/Phase 2
Recruiting	`NCT00082108` - Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry
Recruiting	`NCT00138931` - Genetics of Cardiovascular and Neuromuscular Disease
Completed	`NCT00622453` - Arrhythmias in Myotonic Muscular Dystrophy	N/A
Active, not recruiting	`NCT04038138` - Clinical Trial Readiness Network FSHD France: Prospective 24 Months MRI Study	N/A
Completed	`NCT01451281` - Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy
Not yet recruiting	`NCT05470478` - iBCI Optimization for Veterans With Paralysis	N/A
Completed	`NCT04154098` - Evaluation of a Textile Scapula Orthosis	N/A
Terminated	`NCT02653833` - The Study of Skeletal Muscle Blood Flow in Becker Muscular Dystrophy	Early Phase 1
Not yet recruiting	`NCT06363526` - Effectiveness of 5-week Digital Respiratory Practice in a Group of Children With Duchenne Muscular Dystrophy and Becker Muscular Dystrophy.	N/A
Completed	`NCT01393444` - ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis	N/A
Recruiting	`NCT00912041` - BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia	N/A
Completed	`NCT00866112` - A Randomized Exercise Trial for Wheelchair Users	N/A
Completed	`NCT01882400` - Assessment of Response to Treatment of Osteoporosis With Oral Bisphosphonates in Patients With Muscular Dystrophy	Phase 4
Recruiting	`NCT05726591` - Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders	N/A
Completed	`NCT02815878` - Enhance Wellness for Individuals With Long-Term Physical Disabilities	N/A
Completed	`NCT04035967` - Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities
Not yet recruiting	`NCT06290713` - Vasodilator and Exercise Study for DMD (VASO-REx)	Phase 2
Recruiting	`NCT05230459` - A Study to Evaluate the Safety of AB-1003 (Previously LION-101) in Subjects With Genetic Confirmation of LGMD2I/R9 (Part1)	Phase 1/Phase 2

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Study of Morphology and Functional Magnetic Resonance Imaging (MRI) Muscle Patients With Muscular Dystrophy Type FSHD Benefiting a Physical Training Introduced. — FSHD3

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms