Phase III Study of Idebenone in Duchenne Muscular Dystrophy (DMD)

Muscular Dystrophy, Duchenne Clinical Trial

— DELOS  

Official title:

A Phase III Double-Blind, Randomised, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Idebenone in 10-18 Year Old Patients With Duchenne Muscular Dystrophy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01027884
• Other study ID #: SNT-III-003
• Status: Completed
• Phase: Phase 3
• First received: December 8, 2009
• Last updated: September 23, 2015
• Start date: July 2009
• Est. completion date: April 2014

Study information

• Verified date: September 2015
• Source: Santhera Pharmaceuticals
• Contact: n/a
• Is FDA regulated: No
• Health authority: Belgium: Federal Agency for Medicinal Products and Health ProductsGermany: Federal Institute for Drugs and Medical Devices
• Study type: Interventional

Clinical Trial Summary

The aim of this Phase III study was to assess the efficacy of idebenone on pulmonary function, motor function, muscle strength and quality of life in patients with DMD. Furthermore, the safety and tolerability of idebenone was assessed.

Description:

This study was a Phase III, multicenter, randomized, double-blind, placebo-controlled efficacy and safety study. DMD patients (ambulatory and non-ambulatory) at age 10-18 years were enrolled at sites in Europe and North America. Study subjects were randomized in a 1:1 ratio to receive either idebenone (900 mg/day) or placebo 3 times a day with meals for 52 weeks. The primary endpoint was the difference between Catena®/Raxone® and placebo in the change from Baseline to week 52 in Peak Expiratory Flow (PEF as percent predicted, PEF%p, a measure of respiratory muscle strength) as measured by hospital-based spirometry. PEF was also measured by the patient at home using the hand-held ASMA-1 device (secondary endpoint). Other respiratory endpoints included Forced Expiratory Volume in 1 second (as percent predicted, FEV1%p, an additional measure of respiratory muscle strength) and Forced Vital Capacity (as percent predicted, FVC%p, a measure of restrictive lung disease predictive of morbidity and mortality in DMD).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 65
• Est. completion date: April 2014
• Est. primary completion date: January 2014
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 10 Years to 18 Years

Eligibility

Inclusion Criteria:

1. Patients 10 - 18 years of age at Baseline.

2. Signed and dated informed consent.

3. Documented diagnosis of DMD or severe dystrophinopathy and clinical features consistent of typical DMD at diagnosis (i.e. documented delayed motor skills and muscle weakness by age 5 years). DMD should be confirmed by mutation analysis in the dystrophin gene or by substantially reduced levels of dystrophin protein (i.e. absent or <5% of normal) on Western blot or immunostain.

4. Ability to provide reliable and reproducible repeat PEF within 15% of the first assessment (i.e. Baseline vs. Screening).

5. Patients assessed by the investigator as willing and able to comply with the requirements of the study, possess the required cognitive abilities and are able to swallow study medication.

Exclusion Criteria:

1. Patients dependent on assisted ventilation at Screening and/or Baseline (defined as non-invasive nocturnal ventilation, daytime non-invasive ventilation or continuous invasive ventilation).

2. Patients with documented DMD-related hypoventilation for which assisted ventilation is needed according to current standard of care guidelines (e.g. FVC< 30%) or is required in the opinion of the Investigator.

3. Patients with a percent predicted PEF > 80% at Baseline.

4. Patients unable to form a mouth seal to allow precise respiratory flow measurements and mouth pressures.

5. Symptomatic heart failure (high probability of death within one year of Baseline) and/or symptomatic ventricular arrhythmias.

6. Participation in the previous Phase II or Phase II Extension study (SNT-II-001 or SNT-II-001-E) for idebenone.

7. Participation in any other therapeutic trial and/or intake of any investigational drug within 90 days prior to Baseline.

8. Use of carnitine, creatine, glutamine, oxatomide, or any herbal medicines within 30 days prior to Baseline.

9. Use of coenzyme Q10 or vitamin E (if taken at a dose of 5 times above the daily physiological requirement) within 30 days prior to Baseline.

10. Any previous use of idebenone.

11. Any concomitant medication with a depressive or stimulating effect on respiration or the respiratory tract.

12. Planned or expected spinal fixation surgery during the study period (as judged by the investigator).

13. Asthma, bronchitis/COPD, bronchiectasis, emphysema, pneumonia or the presence of any other non-DMD respiratory illness that affects PEF.

14. Chronic use of beta-2 agonists or any use of other bronchodilating medication (e.g. inhaled steroids, sympathomimetics, anticholinergics).

Please note: Chronic use if defined as a daily intake for more than 14 days.

15. Moderate or severe hepatic impairment or severe renal impairment.

16. Prior or ongoing medical condition or laboratory abnormality that in the Investigator's opinion could adversely affect the safety of the subject.

Please note: Patients who suffer from a severe, unstable condition including (but not limited to) cancer, auto-immune diseases, haematological diseases, metabolic disorders or immunodeficiencies, and who are at risk of an aggravation unrelated to the study condition, can only be included in the study if accepted in writing by the Sponsor's Medical Monitor.

17. Relevant history of or current drug or alcohol abuse or use of any tobacco/marijuana products/smoking

18. Known individual hypersensitivity to idebenone or to any of the ingredients/excipients of the study medication

19. Systemic glucocorticoid therapy

1. Chronic use of systemic glucocorticoid therapy for DMD related conditions within 12 months of Baseline (the "12 month non-use period")

2. More than 2 rounds of acute systemic glucocorticoid burst therapy (of =2 week duration) for non-DMD related conditions within the 12 month non-use period

3. Use of any round of systemic glucocorticoid burst therapy of longer than 2 weeks duration within the 12 month non-use period

4. Use of systemic glucocorticoid burst therapy less than 8 weeks prior to baseline

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Ambulatory Care
• Muscular Dystrophies
• Muscular Dystrophy, Duchenne

Intervention

Drug:
• Placebo
Placebo (900 mg/day) 2 tabl (150 mg each) x 3 times orally with meals
• Idebenone
Idebenone (900 mg/day) 2 tabl (150 mg each) x 3 times orally with meals

Locations

Country	Name	City	State
Austria	Dr. Günther Bernert, Prim. Univ. Doz.	Wien
Belgium	University Hospitals Leuven- Children Hospital	Leuven
France	Hôpital Roger Salengro, CHRU Lille	Lille
France	Prof. Thomas Voit , MD, PhD	Paris Cedex 13
Germany	Universitätsklinikum Essen, Zentrum für Kinderheikunde	Essen
Germany	Universitätsklinik Freiburg Zentrum für Kinderheilkunde und Jugendmedizin	Freiburg
Italy	Fondazione IRCCS "Eugenio Medea"	Bosisio Parini, Lecco
Italy	Azienda Ospedaliera Niguarda Ca' Granda Centro Clinico Nemo	Milan
Italy	Azienda Ospedaliera Universitaria della Seconda Università degli Studi di Napoli	Napoli
Netherlands	Ass. Prof. Jan Verschuuren , MD, PhD	Leiden	P.O. Box 9600
Spain	Hospital Universitario 12 de Octubre	Madrid
Spain	Hospital Universitario y Politécnico La Fe	Valencia
Sweden	Prof. Thomas Sejersen, MD, PhD	Stockholm
Switzerland	CHUV Lausanne Neuropediatrie	Lausanne
United States	Children's Hospital Colorado	Aurora	Colorado
United States	Carolinas Medical Center, Neurosciences and Spine Institute	Charlotte	North Carolina
United States	University of Texas Southwestern Medical Center	Dallas	Texas
United States	University of Florida	Gainesville	Florida
United States	Methodist Neurological Institute	Houston	Texas
United States	Monroe Carell, Jr. Children's Hospital at Vanderbilt	Nashville	Tennessee
United States	The Children's Hospital of Philadelphia	Philadelphia	Pennsylvania
United States	University of California Davis Medical Center	Sacramento	California
United States	Seattle Children's Hospital	Seattle	Washington

Sponsors (1)

Lead Sponsor	Collaborator
Santhera Pharmaceuticals

Countries where clinical trial is conducted

United States,  Austria,  Belgium,  France,  Germany,  Italy,  Netherlands,  Spain,  Sweden,  Switzerland, 

References & Publications (1)

Buyse GM, Voit T, Schara U, Straathof CS, D'Angelo MG, Bernert G, Cuisset JM, Finkel RS, Goemans N, McDonald CM, Rummey C, Meier T; DELOS Study Group. Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glu — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change From Baseline in Percent Predicted Peak Expiratory Flow (PEF) at Week 52	Change from Baseline in Percent Predicted Peak Expiratory Flow (PEF) at Week 52	Baseline and Week 52	No
Secondary	Change From Baseline in Percent Predicted Forced Vital Capacity (FVC) at Week 52	Change From Baseline in Percent Predicted Forced Vital Capacity (FVC) at Week 52	Baseline and Week 52	No
Secondary	Change From Baseline to Week 52 in Muscle Strength	The change from Baseline to Week 52 in muscle strength as measured by Hand-Held Myometry (HHM) was performed following standardized procedures. As almost all patients were non-ambulatory, only analyses of upper limb muscle strength were performed. Results for elbow flexors and for elbow extensors are reported below.The highest value of 3 consecutive measurements with an interval of at least 10 seconds were recorded.; The HHM was measured using MicroFET2, a digital hand held muscle tester. The selected unit of measure was Newtons (N).	Baseline and Week 52	No
Secondary	Change From Baseline to Week 52 in Quality of Life Assessed by PedsQL™ Paediatric Quality of Life Inventory	PedsQL Quality of Life Inventory contains paediatric HRQOL measurements: Physical, Emotional,Social and School Functioning.; Item Scaling: 5-point Likert scale from 0 (Never) to 4 (Almost always). 3-point scale: 0 (Not at all), 2 (Sometimes) and 4 (A lot) for the Young Child (ages 5-7).; Scores are transformed on a scale from 0 to 100 ( 0=100, 1=75, 2=50, 3=25, 4=0) Total Score: Sum of all the items over the number of items answered on all the Scales.; The values reported below are overall scores on Paediatric Quality of Life Inventory in Child/Teen Report. These scores were obtained by averaging scores for all the described subscales. The overall scores range between 0-100 with 0 = worst outcome and 100= best outcome	Baseline and Week 52	No
Secondary	Percentage of Patients Reporting Adverse Events		52 Weeks	Yes

External Links

•   Link