Muscular Atrophy Clinical Trial
Official title:
Mechanisms of Low Protein Diet Supplemented With α-ketoacids on Autophagy and Improving Muscle Wasting in Chronic Kidney Disease: the Role of Autophagy in Muscle Wasting
To investigate the effects of different dietary regimens on muscle wasting, insulin/IGF-1 resistance. Further, to explore whether LPD+KA decrease the activation of autophagy associate with insulin/IGF-1 pathway.
1. Dietary assessment: The composition of the diet will be evaluated through
questionnaire, and analyzed a computer-based nutritional evaluation with Dieta
software.
2. Biochemical data: blood samples will be collected at baseline and every 3 months of
routine examination, such as blood routine, biochemistry, HbA1c, Serum IGF-1, CRP, will
be measured. Homeostatic model assessment score (HOMA-IR) was recorded.
3. Skeletal muscle assessment: the parameters of skeletal muscle will be assessed before
and after dietary intervention for 12 months. Body weight, height, Body mass index,
skeletal muscle mass will be measured by Body composition analyzer. Quadriceps strength
will be assessed with a seated leg press exercise instrument (Keiser Sport, Fresno, CA,
USA) using the five repetition maximum technique. Knee and hip extension power (rate of
generating force) will be assessed with a validated leg power instrument (University
ofNottingham Medical College, Nottingham, UK). Fatigability will be assessed with the
same bilateral leg press exercise used in strength testing.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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