Muscle Spasticity Clinical Trial
Official title:
Optimization of Physical Focal Stimulation Parameters for Improving Spasticity and Identification of Neurophysiological Mechanism
The overall aim of the proposed study is to determine optimal parameter of focal muscle
vibration for improving spasticity and identify neurophysiological mechanism in healthy
subjects.
In investigation I-1, subjects will undergo focal muscle vibration with 40, 80, 120 Hz
frequency at the medial gastrocnemius muscles (mGCM). As a surrogate maker of spasticity,
H-reflex and compound motor action potential (CMAP) of the tibial nerve at mGCM will be
recorded pre, during, and post vibration.
In investigation I-2, subjects will undergo focal muscle vibration with 0.1, 0.3, 0.5 mm
amplitude at mGCM. H-reflex and CMAP of the tibial nerve at mGCM will be recorded pre,
during, and post vibration.
In investigation II, subjects will undergo focal muscle vibration with predetermined
parameters by the investigation I at mGCM. H-reflex and CMAP of the tibial nerve and motor
evoked potential at mGCM will be recorded pre, during, and post vibration.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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