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NCT05988476 Clinical Trial

Investıgatıon of The Effıciency of Pulsed Electromagnetıc Field Therapy and Stretching Exercises

Muscle Injury Clinical Trial

Official title:
Investigation of The Efficiency of Pulsed Electromagnetic Field Treatment and Stretching Exercise In Experimental Skeletal Muscle Injury Model

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05988476
Other study ID # SuleymanDUmesutergan01
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 5, 2022
Est. completion date November 7, 2022

Study information
Verified date August 2023
Source Suleyman Demirel University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time. In the study, animals were divided into 5 groups (Control, INJ, INJ+Exercise, INJ+PEMF, INJ+Exercise+PEMF). Experimental animals were sacrificed on the 7th and 14th days to see the effects of the treatments. At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.

Description:

Purpose: The aim of this study was to evaluate the efficacy of stretching exercise and the pulsed electromagnetic field (PEMF) method in the treatment of muscle injury (INJ). Methods: In this study, a total of 69 Wistar Albino rats were used, five of which were in the preliminary study. The preliminary study was planned to determine the ideal PEMF treatment time. In the study, animals were divided into 5 groups (Control, INJ, INJ+Exercise, INJ+PEMF, INJ+Exercise+PEMF). Experimental animals were sacrificed on the 7th and 14th days to see the effects of the treatments. At the end of the experiment, genetic, histopathological, and immunohistochemical evaluations were made in the muscle tissue.

Recruitment information / eligibility
Status Completed
Enrollment 64
Est. completion date November 7, 2022
Est. primary completion date October 2, 2022
Accepts healthy volunteers No
Gender Female
Age group 10 Months to 11 Months
Eligibility Inclusion Criteria: - Healthy young wistar albino rats Exclusion Criteria: - not having any injury

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Exercise
5 day/week, two week, one session stretching exercises consisting of ten repetitions of one minute
Device:
• Pulsed Electromagnetic Field Therapy
5 day/week, two week,two sessions consisting of 180 minutes

Locations
Country Name City State
Turkey SuleymanDU Isparta

Sponsors (1)
Lead Sponsor Collaborator
Suleyman Demirel University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary Mononuclear cell infiltration, Atrophy and necrosis, Pyknotic nucleus assesment at the end of two weeks hematoxylin-eosin staining two week
Primary VEGF and FGF assesment at the end of two weeks immunohischemical staining two week
Primary TGF-ß1, eNOS assesment at the end of two weeks Quantitative Reverse-Transcriptase Polymerase Chain Reaction (RT-qPCR) two week
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