Lower and Higher Load Resistance Exercise Protocols: Acute Muscle Activation and Skeletal Muscle Hypertrophy

Muscle Hypertrophy Clinical Trial

Official title:

Muscle Fibre Activation is Unaffected by Load and Repetition Duration When Resistance Exercise is Performed to Task Failure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03991117
• Other study ID #: HIREB 0802
• Status: Completed
• Phase: N/A
• Start date: January 4, 2016
• Est. completion date: March 1, 2016

Study information

• Verified date: June 2019
• Source: McMaster University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

How much weight an individual lifts per workout does not dictate the relative increase in muscle size the individual gains following weeks of training, which is contrary to current strength training dogma. Specifically, researchers have concluded that so long as an individual performs resistance exercise with maximum effort, it is not necessary to lift with relatively heavy loads. However, other laboratories, on the basis of surface electromyography measurements, have challenged the thesis that lighter loads can result in the hypertrophy of larger, type II muscle fibres. Therefore, the purpose of this study was to combine surface electromyography measurements with direct measurements of muscle fibre activation to see if muscle fibre activation was truly dependent on load. The investigators hypothesized that all muscle fibres would be activated when the resistance exercise was performed with maximal effort.

Description:

PROCEDURES INVOLVED IN THE RESEARCH

The total time commitment of this study will be ~7 hours. Each participant's first visit (familiarization) will include an interview through where the researchers will determine if there are any reasons that the participant cannot take part in the study. The researchers will explain the study protocol and, upon the participant's consent, the investigators will obtain the participant's knee extension maximum voluntary contraction (MVC) on a dynamometer (Biodex, Shirley, USA) and a 1 repetition-maximum (RM) test on a knee extension machine. Following that, the investigators will determine the next two dates (trial days) in which the participant will come in.

The participant will be asked to come in fasted on two separate trial days, each separated by two weeks, after the participant's familiarization visit. The participant will be required to avoid physical activity 48 hours before each of the three visits. There are four conditions in this study, each varying in relative load and speed of contraction. The participant will complete two conditions on each trial day, one with each leg. The conditions include: 80%RM Normal (80N; 1 eccentric: 1 pause: 1 concentric), 80% Slow (80S; 3:1:3), 30% Normal (30N; 1:1:1) and 30% Slow (30S; 3:1:3). Each condition will include three sets to voluntary failure on a knee extension machine. Before and after each set the participant will perform three MVCs on the dynamometer identical to what the participant did on the familiarization day. The investigators will record the participant's rating of perceived exertion and effort via the Borg scale and electromyography (EMG), respectively. The participant will have one biopsy taken pre-training and two, one per condition/leg, one hour post-training.

The REB Project Number for this study is: 802

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 1, 2016
• Est. primary completion date: March 1, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy

• male

• 18-30 years of age

Exclusion Criteria:

• Have any acute or chronic illness such as cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through a medical history screening questionnaire

• Experience arthritic conditions

• Smoke tobacco products

• Consume any analgesic or anti-inflammatory drug(s), prescription or non-prescription, chronically

• Have a history of neuromuscular complications

• Are on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

• Have an extensive history of RE training in the year prior to study entry.

Related Conditions & MeSH terms

• Hypertrophy
• Muscle Fibre Activation
• Muscle Hypertrophy

Intervention

Behavioral:
• resistance exercise
unilateral knee extensions until fatigue with varying load and speeds of contraction

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
McMaster University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concentration of glycogen in muscle fibres	Histochemical assessment of muscle glycogen via muscle biopsies	three weeks
Primary	Amplitude of electrical activity above the quadriceps muscles	Surface electromyography assessment via electrodes during the unilateral resistance exercise	three weeks