Clinical Trial Details
— Status: Active, not recruiting
Administrative data
| NCT number |
NCT05777629 |
| Other study ID # |
nol |
| Secondary ID |
|
| Status |
Active, not recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
February 28, 2021 |
| Est. completion date |
June 1, 2023 |
Study information
| Verified date |
March 2023 |
| Source |
University of Gaziantep |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational
|
Clinical Trial Summary
Multiple Sclerosis (MS) is an autoimmune disease characterized by inflammation, demyelination
and axon damage. Affecting approximately 2.5 million individuals around the world and seen
mostly in young adults, MS can cause different levels of disability in functional activities,
cause limitations in social and professional life, and impair quality of life. Multiple
sclerosis is thought to be an autoimmune disease that develops on the basis of genetic
predisposition and environmental factors. Nutritional habits and physical activity are
important environmental factors. These can be effective in the course of MS and change the
quality of life. Compatibility of nutrition with the Mediterranean diet and providing
adequate physical activity may be beneficial in increasing physical and mental well-being in
general, and therefore the quality of life of the person.
In our country, there is not enough information about the ongoing nutritional habits and
physical activity levels of MS patients in their daily lives, and quality of life studies are
limited. Our limited knowledge on these issues narrows the possibility of movement in an area
that can be corrected in MS patients and thus have a positive impact on their quality of
life. The aim of this study is to determine compliance with the Mediterranean diet, the
tendency to use various nutritional supplements, physical activity habits, walking-related
problems and quality of life in MS patients and to evaluate whether there is a significant
relationship between these parameters.
Description:
Clinical studies examining the effects of various dietary patterns on MS are ongoing, and
evidence is still lacking regarding the use of any specific dietary therapy for individuals
with MS. In general, individuals living in high-income western countries where the disease is
more common; They lead a sedentary life, are less exposed to sunlight, and are fed a
high-energy diet rich in animal-derived saturated fats and refined sugar.
The Mediterranean diet is a nutritional model that is universally thought to improve health,
and it is known that the Mediterranean diet has beneficial effects in the prevention and
treatment of chronic diseases.The major difference between the Mediterranean diet and the
Western-style diet is the source and amount of dietary fat and carbohydrates. The
Mediterranean diet is rich in foods containing monounsaturated fat (especially omega-3),
antioxidant vitamins and minerals (vitamins A, C, E, folic acid, selenium, zinc, calcium),
which are thought to have positive effects on the prevention and course of MS.
Preferring vegetable oils instead of animal fats in Mediterranean type diet, preferring fish
instead of red meat consumption, preferring low-fat / fat-free milk and dairy products,
limiting the intake of simple sugar and refined carbohydrates, increasing the consumption of
fruits and vegetables rich in pulp and antioxidants. It is thought that this type of
nutrition may positively affect the course and treatment of immune diseases by reducing
inflammation.
Although there is no effective clinical evidence for the application of nutritional support
as complementary therapy in MS patients, it is known that patients often use various
nutritional supplements to reduce symptoms that negatively affect their quality of life. It
is also important to determine the frequency of current nutritional support use in order to
prevent unconscious use of nutritional support in the group.
Because the most common symptoms of MS are muscle weakness, individuals with MS are often
less physically active than age-matched adults
All these negativities result in decreased functional activities, loss of mobility and
balance problems.
Walking and, in a broader sense, mobility are functions that are frequently affected in MS
and have a high negative impact on quality of life. Gait problems are not uncommon in MS, and
it is reported that a significant portion of individuals in this group are adversely affected
by their daily living activities.
The aim of this study is to determine compliance with the Mediterranean diet, the tendency to
use various nutritional supplements, physical activity habits, walking-related problems and
quality of life in MS patients and to evaluate whether there is a significant relationship
between these parameters.
