Investigation of the Effects of Selective Exercise Training in Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

Investigation of the Effects of Selective Exercise Training on Muscle Architecture, Balance, Function and Fatigue in Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04853654
• Other study ID #: ipekkirmaci
• Status: Completed
• Phase: N/A
• Start date: September 15, 2018
• Est. completion date: June 15, 2020

Study information

• Verified date: December 2021
• Source: Sanko University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Selective exercise programs specific to muscle groups, with the workload to be done in line with the muscle's own structure, can enable more strength to be released with less fatigue in MS, and this increase in strength can increase balance and functional activities. to determine the effects of type training (selective exercise training), eccentric and concentric training on function, balance, fatigue and muscle architecture.

Description:

Recovery and enhancement of muscle function in MS is one of the main goals in physiotherapy and rehabilitation. In literature studies, it is stated that eccentric and concentric exercises are effective exercise approaches in increasing strength and reducing fatigue. However, the best exercise method is not yet clear in terms of providing better performance adaptation with less fatigue. Considering the architectural features of the lower extremity muscles, it is aimed to increase the angle of pennation with programs that include concentric strengthening of the quadriceps, gastro-soleus and gastrocnemius muscles, which are suitable muscle groups to produce large forces by design. With programs that include eccentric strengthening of the hamstring and tibialis anterior muscles that function in a wide range of motion and have high excursion ability, it is aimed to increase fiber length.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: June 15, 2020
• Est. primary completion date: April 15, 2020
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• Between the ages of 18-50,
• With an Extended Disability Status Scale (EDSS) score of 4 or less,
• No regular exercise habit
• Able to walk on the treadmill,
• No pregnancy,
• Not receiving corticosteroid treatment in the last month,
• Fampridine etc. in the last 1 month. not taking medication,
• Patients who have not received Botox treatment in the last 6 months Exclusion Criteria: patients who do not agree to volunteer

Related Conditions & MeSH terms

• Exercise
• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• exercise
exercise training for 8 weeks

Locations

Country	Name	City	State
Turkey	Zekiye Ipek Katirci Kirmaci	Gaziantep

Sponsors (1)

Lead Sponsor	Collaborator
Sanko University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	muscle architecture parameter 1	The pennation angle were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
Primary	muscle architecture parameter 2	The fiber length were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
Primary	muscle architecture parameter 3	The muscle thickness were evaluated with Ultrasound	Change from Baseline at 8th weeks and 12th weeks
Primary	Muscle strength	low extremity muscles were evaluated with hand dynamometer	Change from Baseline at 8th weeks and 12th weeks
Secondary	walking fatigue	Walking Fatigue Index	Change from Baseline at 8th weeks and 12th weeks
Secondary	perceived fatigue	Fatigue Severity Scale	Change from Baseline at 8th weeks and 12th weeks
Secondary	physical fatigue	Modified Borg Scale before and after 6-minute walking test	Change from Baseline at 8th weeks and 12th weeks
Secondary	static balance	Single standing tests	Change from Baseline at 8th weeks and 12th weeks
Secondary	dynamic balance	4 square step tests	Change from Baseline at 8th weeks and 12th weeks
Secondary	Functional activities 1	timed-up go test	Change from Baseline at 8th weeks and 12th weeks
Secondary	Functional activities 2	2-minute walk test	Change from Baseline at 8th weeks and 12th weeks
Secondary	Functional activities 3	25-feet walk test	Change from Baseline at 8th weeks and 12th weeks