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NCT04793087 Clinical Trial

Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis (COCON)

Multiple Sclerosis Clinical Trial

— COCON  

Official title:
Post-COntrast 3D SE T1 Versus Coronal SE T1-WI MRI in Detecting Optic Neuritis in Patients Presenting With Acute Visual Loss and Otherwise Normal Ophthalmological Examination

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04793087
Other study ID # CE_20200204_2_ALR
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date August 30, 2020

Study information
Verified date March 2021
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal suggestive of inflammation whereas brain examination is preferably performed using a 3D T1 sequence to highlight signs of spatial dissemination and lesions suggestive of multiple slerosis (MS). No study has yet investigated the detection capabilities of 3D T1 for the detection of optic nerve inflammation. The objective of this retrospective study was to determine whether a single 3D T1 sequence allows simultaneous exploration of the optic nerve and the brain for the positive diagnosis of optic neuropathy and/or MS.

Recruitment information / eligibility
Status Completed
Enrollment 1200
Est. completion date August 30, 2020
Est. primary completion date January 1, 2018
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age > 18 years - Decrease in visual acuity explored in MRI between january 2018 and january 2020 Exclusion Criteria: - Past history of episode of Optic neuritis

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Magnetic Resonance Imaging
Comparing 3D T1 versus coronal T1 MRI in detecting Optic Neuritis

Locations
Country Name City State
France Hôpital Fondation Adolphe de Rothschild Paris Ile-de-France

Sponsors (1)
Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Detection of optic neuropathies using MRI MRI comparison of the diagnostic performance of the 3D T1 sequence and the T1 coronal in the detection of optic neuropathies. 1 hour
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