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NCT04789551 Clinical Trial

T Cell Profiling in Patients With Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:
T Cell Profiling in Patients With Multiple Sclerosis

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT04789551
Other study ID # IRB-P00037843
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date June 1, 2024
Est. completion date December 1, 2025

Study information
Verified date November 2023
Source Boston Children's Hospital
Contact Lifei Hou, PhD
Phone 617-713-8154
Email lifei.hou@childrens.harvard.edu
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this research study is to to learn more about the body's immune response in patients with multiple sclerosis (MS). In MS, the body's immune cells mistakenly attack an important part of the nerves of the brain and spinal cord. The immune cells responsible for attacking the nerves in MS patients is primarily the T cells. A marker was recently discovered that might specifically identify these damaging T cells from all other T cells in the body. Understanding which T cells cause the damage in MS patients and understanding more about these specific T cells may help doctors better understand how MS occurs and could possibly prevent MS in the future.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 40
Est. completion date December 1, 2025
Est. primary completion date July 1, 2025
Accepts healthy volunteers No
Gender All
Age group 13 Years to 20 Years
Eligibility MS Group Inclusion criteria -diagnosis of multiple sclerosis and present to the neurology clinic for a regular checkup or are admitted to the inpatient floor with acute symptoms. Exclusion criteria - Have an active infection - Take T cell modulating drugs Control Group Inclusion criteria -scheduled for elective surgery - without any immunological diseases. Exclusion criteria - Have an active infection.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Blood Sample
a blood sample will be collected

Locations
Country Name City State
United States Boston Children's Hopsital Boston Massachusetts

Sponsors (1)
Lead Sponsor Collaborator
Boston Children's Hospital

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary T cell populations compare T cell populations between patients with Multiple Sclerosis and healthy controls up to one week
See also
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Completed NCT04147052 - iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis N/A
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