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Prebiotic vs Probiotic in Multiple Sclerosis — MS  

Multiple Sclerosis Clinical Trial

Official title:
Prebiotic and Probiotic Treatment Trial in Multiple Sclerosis

Clinical Trial Summary

This is a randomized crossover-designed study to explore the immunologic effects of Prebiotics, as opposed to direct supplementation with beneficial bacteria (Probiotics) in the immune system of patients with MS and Clinically Isolated Syndrome (CIS). Eligible patients will take 6 weeks of two different supplements - Prebiotics and Probiotics. Participants will be randomly assigned to take either of two agents for 6 weeks as their first supplement. Then, participants enter a 6-week washout period. After the washout period, participants will take the second supplement for 6 weeks. After taking the second supplement, participants will have a 6-week washout period.

Clinical Trial Description

Soluble fibers (prebiotics) are fermented by beneficial bacteria (probiotics) in the colon to produce short-chain fatty acids (SCFAs) which are the main source of nutrition for the cells in the gut. It has been reported that the fermentable fiber inulin and SCFAs may exert some beneficial effects including anti-inflammatory effect on the immune system. To date, the effect of supplementation with fermentable dietary fiber, such as prebiotics in patients with Multiple Sclerosis (MS) has not been investigated. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04038541
Study type Interventional
Source Columbia University
Contact
Status Completed
Phase N/A
Start date March 11, 2020
Completion date December 30, 2023
View Details
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