Multiple Sclerosis Clinical Trial
Official title:
Follow-up of Physical, Psychosocial and Cognitive Influences in Persons With Multiple Sclerosis: a Prospective Cohort Study
Multiple sclerosis (MS) is a chronic, progressive and demyelinating disease that affects more
than 2.5 million people in the world and is frequently seen in young adults between 20 and 40
years of age, especially in women. Although the exact MS in Turkey is not known, it is
estimated as 40/100,000. According to epidemiological studies in recent years, the prevalence
and incidence of MS tend to increase. The most common clinical signs and symptoms include
loss of sensation in the extremities, partial or total vision loss, acute or subacute motor
dysfunction, cognitive impairment, double vision and gait dysfunction.
Currently, MS has no definitive cure. Progressive symptoms related to the disease need to be
managed in order to increase and maintain the quality of life of individuals with MS.
Pharmacological, physiotherapeutic and psychotherapeutic methods are the most effective
effective methods in the management of symptoms. However, the efficacy of these methods has
been demonstrated in clinical trials. The outcomes cannot be generalized to the entire MS
population because of the inclusion and exclusion criteria that exist in clinical trials. In
addition, clinical trials are conducted at a specified time interval (usually a short time
interval is selected) and generally, short-term results are provided. In order to better
understanding the course of MS, it is of utmost importance that long-term follow-up studies
are carried out where as many patients are included and patients are followed from the date
of initial diagnosis. The aim of this study is to investigate the change of physical,
psychosocial and cognitive characteristics over time and the correlated variables.
The volunteers from MS patients who attend routine control of the MS outpatient clinic of
Dokuz Eylül University Hospital will participate in the study. Physical and clinical
assessments will be performed by physicians and physiotherapists, and cognitive evaluations
will be performed by psychologists with 6-month intervals.
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