Multiple Sclerosis Clinical Trial
Official title:
Clinical Profiling, Manifestation and Assessment of Walking-related Performance Fatigability in Patients With Multiple Sclerosis: a Cross Sectional Study
The primary goal of this interventional study is to objectively examine the prevalence of
walking-related performance fatigability, together with the psychometric properties of its
measuring parameters. The secondary aim is to investigate the relation of other clinical
symptoms to walking-related performance fatigability.
The following three research questions will be addressed:
1. How prevalent is walking-related performance fatigability and what are the psychometric
properties of fatigability formulas in preparation of use as experimental outcome
measure?
2. What are associated symptoms of walking-related motor fatigability and how long does
this manifest?
3. What is the relationship between cognitive fatigability and walking-related performance
fatigability?
participants perform two six-minute walking test (6MWT), with 3-5 days in between. Before and
after the 6MWT, three screenings test (spasticity, muscle strength, balance) are executed and
the participants have to indicate the severity of eleven possible symptoms (= symptom
inventory, SI) on a VAS scale. These screening tests and SI are continued every 10 minutes
for half an hour. During a third test session, participants perform a 6-minute vigilance
alphabet test in rest and while doing a 6MWT to investigate the relationship between
cognitive and motor fatigability.
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