PET Study in Multiple Sclerosis

Status Recruiting

Clinical Trial Summary

While both conventional and advanced MRI techniques offer important insights into MS pathophysiology, important aspects of this inflammatory disorder are undetectable with existing MRI technology. In Multiple Sclerosis (MS), there is growing interest in PET as an imaging modality that can increase the investigator's understanding of the disease processes and may add to an understanding of MS phenotype, particularly when combined with advanced MRI techniques such as myelin water imaging.

Clinical Trial Description

This is an exploratory study. PBR28 PET scan is new, promising and exploratory endpoints in MS clinical trials, making sample size estimation difficult.

A separate pre-screening consent form will be issued for the TSPO rs6971 polymorphism and eGFR blood samples, a separate pre-screening step. Eligible participants, according to their TSPO rs6971 polymorphism will be presented a separate study consent form to continue into the clinical trial.

Study Assessments include 1 PET scan, 1 MRI scan, OCT, EDSS exam, physical exam, cognitive questionnaires, etc. ;

Study Design

Related Conditions & MeSH terms

Multiple Sclerosis
Multiple Sclerosis, Chronic Progressive
Sclerosis

Clinical Trial Details

NCT number	NCT03787446
Study type	Observational
Source	University of British Columbia
Contact	Janice Jong
Phone	604-827-1892
Email	janice.jong@ubc.ca
Status	Recruiting
Phase
Start date	March 26, 2019
Completion date	September 2020

View Details

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