Neurodynamic Interventions for Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

Effects of Neurodynamic Interventions to Multimodal Physical Therapy in Patients With Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03595631
• Other study ID #: PI-URJC 572
• Status: Completed
• Phase: N/A
• Start date: July 26, 2018
• Est. completion date: October 4, 2018

Study information

• Verified date: October 2018
• Source: Universidad Rey Juan Carlos
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized, parallel-group, clinical trial will be conducted to compare the immediate effects of the inclusion of a neurodynamic intervention into a multimodal physiotherapy program on pressure pain sensitivity, pain and manual dexterity in patients with multiple sclerosis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: October 4, 2018
• Est. primary completion date: September 15, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• a diagnosis of multiple sclerosis according to the modified McDonald criteria;

• symptoms of paresthesia and lack of sensitivity in the upper extremity;

• Expanded Disability Status Scale (EDSS) between 0 and 6.5 points;

• absence of cognitive deficit.

Exclusion Criteria:

• any exacerbation of multiple sclerosis during the previous 3 months;

• previous hand surgery or steroid injections treatment in the upper extremity;

• multiple diagnoses on the upper extremity (e.g., cervical radiculopathy);

• cervical, shoulder, or upper extremity trauma;

• other comorbid musculoskeletal medical conditions;

• mini-mental state examination <25

Related Conditions & MeSH terms

• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• Physical Therapy
Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week.
• Physical Therapy plus Neurodynamic
Patients will receive 5 session of multimodal physiotherapy treatment of 30min duration including low-load strength exercises, soft tissue mobilization and muscle-tendon stretching exercises twice per week. In addition, they will also receive bilateral nerve slider neurodynamic interventions targeting the median, ulnar and radial nerves.

Locations

Country	Name	City	State
Spain	César Fernández-de-las-Peñas	Alcorcon	Madrid

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Rey Juan Carlos

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in pressure pain sensitivity	Pressure pain threshold over the median, ulnar and radial nerves, second metacarpal and tibialis anterior	Baseline and one week after the last treatment session
Secondary	Changes in upper extremity pain intensity before and after the intervention	A Numerical Pain Rate Scale (NPRS, 0-10) will be used to record the mean and the worst intensity of pain in te upper extremity	Baseline and one week after the last treatment session
Secondary	Changes in light touch detection threshold	Light touch detection threshold will be assessed with a standardized set of modified twenty von Frey hairs	Baseline and after treatmentBaseline and one week after the last treatment session
Secondary	Changes in manual dexterity	Bilateral manual dexterity was bilaterally assessed using the nine-hole peg test	Baseline and one week after the last treatment session