Multiple Sclerosis Clinical Trial
Official title:
Effects of Low-intensity Interval Walking With Blood Flow Restriction on Gait Speed and Functional Impairments in Patients With Severe Multiple Sclerosis: a Pilot Study
The aim of the study is to evaluate the safety, feasibility and initial efficacy of an
interval-based walking training at low speed performed with blood flow restriction (BFR) on
gait speed and functional impairments in patients with Multiple Sclerosis (MS).
Patients with severe MS will be recruited at outpatient rehabilitation clinics (University
Hospital of Ferrara). Eligible participants will be randomized to interval walking training
with BFR (the experimental group) or conventional exercise therapy (the control group)
according to a blocked-randomization stratified by gender with 1:1 ratio. Both groups will
receive 12 rehabilitative sessions over 6 weeks, for a 2 sessions/week pattern.
The experimental group will undergo interval-based walking training at a slow speed according
to a walk:rest ratio of 1:1 for a total of 6 minutes, to be repeated 5 times. Blood flow
restriction, applied to the proximal thigh, will be set at a maximum of 40% of systolic blood
pressure. The control group will be treated with conventional therapy.
Changes in gait speed, endurance, balance, lower limbs strength and quality of life will be
assessed at baseline, at the end of training, and at follow up.
The proposed training modality has never been tested in patients with MS and, if the
hypotheses were supported by the results, might be a novel tool to improve muscle strength
with a positive impact on gait disabilities, balance and quality of life for patients with
MS.
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