Stylistic Memory Enhancement

Multiple Sclerosis Clinical Trial

— SME  

Official title:

Stylistic Memory Enhancement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03206034
• Other study ID #: E-769-13
• Status: Completed
• Phase: N/A
• First received: June 27, 2017
• Last updated: June 29, 2017
• Start date: March 1, 2013
• Est. completion date: December 31, 2015

Study information

• Verified date: June 2017
• Source: Kessler Foundation
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: December 31, 2015
• Est. primary completion date: December 31, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 59 Years

Eligibility

Inclusion Criteria:

Clinically definite MS between the ages of 18 and 59. Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.

Exclusion Criteria:

• History of alcohol or drug abuse/dependence,

• Major psychiatric disturbance (e.g. bipolar disorder, schizophrenia) and neurological history other than MS.

• Corticosteroid use within the last month prior to the participation.

• Less than 1 month post most recent exacerbation.

Related Conditions & MeSH terms

• Multiple Sclerosis

Intervention

Behavioral:
• Stylistic Memory Enhancement

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Kessler Foundation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	California Verbal Learning Test (CVLT-II- Total learning	Measure of change in new learning	Baseline and post-intervention (5 weeks between testing sessions)
Secondary	Memory Functioning Questionnaire	Measure of change in Self-report of everyday memory functioning	Baseline and post-intervention ( 5 weeks between testing sessions)