Multiple Sclerosis Clinical Trial
Official title:
Changes in Perceived Fatigue and Step Counts Before and After Rehabilitation. A Prospective, Single-center, Longitudinal Observational Study.
The primary objective is to evaluate changes in fatigue and physical activity (step counts)
before and after rehabilitation in patients with MS (EDSS 3-6.5).
The association of changes in fatigue and physical activity will also be analyzed for disease
severity (EDSS), age, emotional status (depression) of the participants.
Around 2 million people worldwide have multiple sclerosis (MS) and it is the most common
neurological disease in young adults. The greatest incidence of MS is found in Europe (108
per 100'000). Over 50% of the patients with MS suffer from fatigue and reduced physical
activity. The association between inactivity and fatigue is low in patients with mild
disability.
Rehabilitation in Valens includes intensive strength and endurance training. Endurance and
walking improve in most patients, evaluated during rehabilitation with the Timed-Up and Go
(TUG) and 2 minute walking tests (2MWT). However, Clinic Valens occasionally gets feedback
from physical therapists in the ambulatory setting, that outcome after rehabilitation is
sometimes poor and some patients with MS (pwMS) seem to be over trained, less mobile, more
fatigued and need to recover for several weeks. Physical therapists in Valens know that
training is fatiguing. If they knew how many, and which patients are more fatigued and less
active after rehabilitation they could reduce treatment intensity and prevent overtraining.
To the knowledge of the investigators no study evaluated changes after rehabilitation in
fatigue, assessed with a disease specific questionnaire (FSMC), and mobility at home using
accelerometers. Potential predictors of poor outcome are disease severity (EDSS),
pre-rehabilitation fatigue and depression.
The primary goal of this study therefore is to evaluate changes in fatigue and physical
activity (step counts) in pwMS assessed before rehabilitation, after rehabilitation and at 2
months follow-up.
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