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NCT02869360 Clinical Trial

Correlation Between PET and Advanced MRI in Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:
Pilot Study of Positron Emission Tomography (PET) Imaging: Correlations With Advanced Magnetic Resonance Imaging in Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02869360
Other study ID # CNS-2016-293
Secondary ID
Status Completed
Phase
First received
Last updated
Start date October 2016
Est. completion date October 2, 2019

Study information
Verified date October 2019
Source University of British Columbia
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Traditional Magnetic Resonance Imaging (MRI) in Multiple Sclerosis (MS) has enabled clinicians to measure disease activity but there are inherent limitations. Clinical/radiographic dissociation can be seen in some patients and the abnormalities are not specific.

This pilot study is an opportunity to determine the relationship between quantitative advanced MRI measures and OCT with PET measurements of microglial activation and myelin health.

Recruitment information / eligibility
Status Completed
Enrollment 14
Est. completion date October 2, 2019
Est. primary completion date October 2, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Diagnosed with Multiple Sclerosis according to the 2011 McDonald criteria.

- Aged 18 to 60

- High or mixed affinity binder to rs6971 TSPO polymorphism

Exclusion Criteria:

- Pregnant or breastfeeding

- Suffering from an unstable medical condition

- Have a neurological or ocular disorder other than MS

- Any contra-indications to MRI

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Canada MS Clinical Trials Group - UBC Vancouver British Columbia

Sponsors (2)
Lead Sponsor Collaborator
University of British Columbia Teva Pharmaceuticals USA

Country where clinical trial is conducted

Canada, 

Outcome
Type Measure Description Time frame Safety issue
Primary Whole Brain PBR28 binding Baseline
Secondary Lesional PiB binding Baseline
Secondary Myelin Water Imaging Baseline
Secondary MR Spectroscopy (Total NAA, NAA/Cr, mI) Baseline
Secondary Optical Coherence Tomography (RNFL thickness) Baseline
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