Motor Imagery Training in Persons With Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

The Effect of Telerehabilitation Based Motor Imagery Training on Gait and Balance Performance of the Persons With Multiple Sclerosis: A Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02781142
• Other study ID #: 2628-GOA
• Status: Completed
• Phase: N/A
• First received: May 17, 2016
• Last updated: March 30, 2018
• Start date: May 2016
• Est. completion date: November 2017

Study information

• Verified date: March 2018
• Source: Dokuz Eylul University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Motor imagery training facilitates the neural plasticity with increasing the neuronal cortical pathways in the brain. Motor imagery training is an effective way in stroke survivors. However, its effects in persons with multiple sclerosis (MS) are not known. Additionally, telerehabilitation based motor imagery training is very rare treatment way which requires more research. Therefore, this study aims to investigate the effect of telerehabilitation based motor imagery training on gait and balance performance of the persons with MS.

The participants will be allocated into three groups, including motor imagery training, wait-list control group, and healthy control group.

All the assessments will be performed before and after the training in the 8-week motor imagery training group. The participants in the control group will underwent the assessment with a 8-week interval. The healthy participants will be assessed only one.

The motor imagery training will be designed for the individual basis with following standard protocols. It will be applied two times a week for 8 weeks. The first one and/or two sessions will be performed in the clinic, the other will be performed at the patients' home with a video-conference telerehabilitation technique.

Description:

Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. It is the most common neurological disease which causes progressive gait and balance disorders in young adults. The previous studies have indicated that home care and treatment services, which accelerates the healing process and makes the one feel better, are more preferred by the patients. Persons with MS are commonly not able to access the institutional rehabilitation services because of their disability and/or home location. It restricts the participation of the persons with MS and their treatment benefits. In recent years, the telerehabilitation programs are increasing to overcome this problem. Motor imagery training also stands as a good option in the rehabilitation programs. Motor imagery is a mental process by which an individual rehearses or simulates a given action. Motor imagery training facilitates the neural plasticity with increasing the neuronal cortical pathways in the brain. Motor imagery training is an effective way in stroke survivors. However, its effects in persons with MS are not known. Additionally, telerehabilitation based motor imagery training is very rare treatment way which requires more research.

The aim of this study is to investigate the effect of telerehabilitation based motor imagery training on gait and balance performance of the persons with MS.

The participants will be allocated into three groups, including motor imagery training group, control group, and healthy control group. The persons with MS will be recruited from the outpatient MS clinic of Dokuz Eylul University, and the healthy participants will be recruited from the stuff of Dokuz Eylul University.

The inclusion and exclusion criteria assessments and the neurological examination will be performed by a blinded neurologist specialized in MS. The cognition, fatigue, depression, and quality of life assessment will be performed by a blinded neuropsychologist. The remaining assessments, including walking, balance, and motor imagery abilities will be assessed by a blinded physiotherapist. All the assessments will be performed before and after the training in the 8-week motor imagery training group. The participants in the control group will underwent the assessment with a 8-week interval. The healthy participants will be assessed only one.

The motor imagery training will be designed for the individual basis with following standard protocols. It will be applied two times a week for 8 weeks. The first one and/or two sessions will be performed in the clinic, the other will be performed at the patients' home with a video-conference telerehabilitation technique.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: November 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Diagnosis of multiple sclerosis

• Having the Expanded Disability Status Scale 0 - 4.0

• Relapse-free period at the last 3 months

• Enough computer use ability

• Having computer and internet connection

Exclusion Criteria:

• Having severe musculoskeletal, cardiovascular, pulmonary, or metabolic disease

• Severe cognitive impairment

• Pregnancy

Related Conditions & MeSH terms

• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• Motor imagery training
The motor imagery training will be designed for the individual basis with following standard protocols. It will be applied two times a week for 8 weeks. The first one and/or two sessions will be performed in the clinic, the other will be performed at the patients' home with a video-conference telerehabilitation technique.

Locations

Country	Name	City	State
Turkey	Dokuz Eylul University Hospital, MS Outpatient Clinic	Izmir
Turkey	Dokuz Eylul University, School of Physical Therapy and Rehabilitation	Izmir

Sponsors (1)

Lead Sponsor	Collaborator
Dokuz Eylul University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dynamic Gait Index		Change from Baseline at 8 weeks
Secondary	Expanded Disability Status Scale		At Baseline
Secondary	Kinesthetic and Visual Imagery Questionnaire (KVIQ)-10		Change from Baseline at 8 weeks
Secondary	Movement Imagery Questionnaire—Revised Second Edition (MIQ-RS)		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for 2-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for 5-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for 10-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for Timed 25-Foot Walk		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for Timed Up and Go Test		Change from Baseline at 8 weeks
Secondary	Mental Chronometry for Five Times Sit to Stand Test		Change from Baseline at 8 weeks
Secondary	2-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	5-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	10-Meter Walk Test		Change from Baseline at 8 weeks
Secondary	Timed 25-Foot Walk		Change from Baseline at 8 weeks
Secondary	2-Minute Walk Test		Change from Baseline at 8 weeks
Secondary	Twelve Item MS Walking Scale		Change from Baseline at 8 weeks
Secondary	Timed Up and Go Test		Change from Baseline at 8 weeks
Secondary	Five Times Sit to Stand Test		Change from Baseline at 8 weeks
Secondary	Curl-up Test		Change from Baseline at 8 weeks
Secondary	Activities-specific Balance Confidence Scale		Change from Baseline at 8 weeks
Secondary	Postural Stability Test by Balance System™		Change from Baseline at 8 weeks
Secondary	The Limits of Stability Test by Balance System™		Change from Baseline at 8 weeks
Secondary	Fall Risk Test by Balance System™		Change from Baseline at 8 weeks
Secondary	Modified Fatigue Impact Scale		Change from Baseline at 8 weeks
Secondary	Hospital Anxiety and Depression Scale		Change from Baseline at 8 weeks
Secondary	Multiple Sclerosis International Quality of Life Questionnaire		Change from Baseline at 8 weeks
Secondary	Symbol Digit Modalities Test		Change from Baseline at 8 weeks
Secondary	Selective Reminding Test		Change from Baseline at 8 weeks
Secondary	10/36 Spatial Recall Test		Change from Baseline at 8 weeks