Multiple Sclerosis Clinical Trial
Official title:
Post-transfusion Platelet Count
The purpose of this study is to identify how the platelet count, complement system and endothelial markers are affected over time, after platelet transfusion in 4 different hematological patient groups.
Patients who are hospitalized at the Clinic for Hematology Diseases at the Skåne University
Hospital (SUS) in Lund, Sweden with a central venous catheter or port-a-cath and should
receive platelet transfusion due to thrombocytopenia are asked to participate in the study.
Some patients who are being considered for platelet transfusions on several occasions will
be able to attend more than one time in this study. After signed informed consent blood
samples are drawn from the central line before, immediately after and then approximately. 1,
4, 8, 16 and 24 hours following the platelet transfusion. The platelet count (PLC) will then
be taken daily following 4 days.
Sample size. Data from previous studies (Norol-98) shows that the PLC after platelet
transfusion rises by 33 ± 25 x109/L (mean ± SD) 12 hours post-transfusion in patients with
acute myeloid leukemia or pre-conditioning prior to bone marrow transplantation. The
investigators want to show the same rise in the PLC after 12 hours with 80% power and 5%
alpha risk of error for each group resulting in the sample size 13 per group and a total of
65 patients.
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Observational Model: Cohort, Time Perspective: Prospective
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