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NCT02509897 Clinical Trial

Normobaric Hypoxic Training and Multiple Sclerosis

Multiple Sclerosis Clinical Trial

— MS_EPOXI  

Official title:
Cardiorespiratory, Metabolic and Immunoregulatory Response to Hypoxia in Multiple Sclerosis Patients: A Pilot Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02509897
Other study ID # EpoxiMet
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 2015
Est. completion date July 2018

Study information
Verified date July 2022
Source Charite University, Berlin, Germany
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To study the effects of normobaric hypoxic training on cardiorespiratory fitness, resting, postprandial and exercise activity energy expenditure, immunoregulatory functions and serum erythropoietin levels in relapsing-remitting multiple sclerosis patients.

Recruitment information / eligibility
Status Completed
Enrollment 39
Est. completion date July 2018
Est. primary completion date December 2017
Accepts healthy volunteers No
Gender All
Age group 20 Years to 60 Years
Eligibility Inclusion Criteria: - stable immunomodulatory therapy - expanded disability status scale score < 4.5 - body mass index 18.5 - 29.9 kg/m2 Exclusion Criteria: - clinically relevant heart, lung, liver, and kidney diseases

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Hypoxic training
Hypoxic training 3 times per week four four weeks
• Normoxic training
Normoxic training 3 times per week four four weeks

Locations
Country Name City State
Germany Experimental & Clinical Research Center Berlin

Sponsors (1)
Lead Sponsor Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

References & Publications (1)

Mähler A, Balogh A, Csizmadia I, Klug L, Kleinewietfeld M, Steiniger J, Šušnjar U, Müller DN, Boschmann M, Paul F. Metabolic, Mental and Immunological Effects of Normoxic and Hypoxic Training in Multiple Sclerosis Patients: A Pilot Study. Front Immunol. 2 — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Activity energy expenditure measured by indirect calorimetry (respiratory chamber) Change from baseline at 4 weeks
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