Multiple Sclerosis Clinical Trial
— CortHaemOfficial title:
Investigating Baseline Cortical Haemodynamics in Multiple Sclerosis
NCT number | NCT02481882 |
Other study ID # | 15037 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | January 2017 |
Est. completion date | October 2019 |
This study will provide information on cortical haemodynamics in MS patients to address the discrepancies reported in previous literature, allowing further insight into the role of haemodynamics in the disease. It will also instruct us as to the most effective scanning protocols for future research. Developing a suitable protocol for studying perfusion longitudinally may also enable identification of new therapeutic interventions to normalise any perfusion abnormalities in MS patients.
Status | Recruiting |
Enrollment | 80 |
Est. completion date | October 2019 |
Est. primary completion date | October 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years to 80 Years |
Eligibility |
Inclusion Criteria (Healthy Volunteers): - Male or female volunteers who are between the ages of 21 and 80. - Able to give voluntary written informed consent to participate in the study. - Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures. Inclusion Criteria (Patients): - Diagnosed with Multiple Sclerosis. - Male or female volunteers who are between the ages of 21 and 80. - Able to give voluntary written informed consent to participate in the study. - Able to understand the requirements of the study, including anonymous publication, and agree to co-operate with the study procedures. Exclusion Criteria: - Any history of neurological illness other than MS. - Known hypersensitivity to any MR or X-Ray contrast agent. - Any history of renal failure or disease. - Any history of allergies. - Any history of circulation problems (vascular disease). - Pregnancy or breastfeeding. - MRI contraindications as screened on safety questionnaire (e.g. metal implants or pacemaker). - Have taken part in any other clinical study within the previous 3 months.# - Any contraindications provided from MRI or contrast agent safety forms. |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Queen's Medical Centre | Nottingham | Nottinghamshire |
Lead Sponsor | Collaborator |
---|---|
University of Nottingham |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral Blood Flow | A short MRI scan is able to quantify the amount of blood perfusion into brain tissue (to be performed with and without the gadolinium contrast agent). | 1 hour | |
Secondary | Arterial Cerebral Blood Volume | A short MRI scan is able to quantify the volume of arterial blood in a volume of brain tissue. | 1 hour | |
Secondary | Arterial Transit Time | A short MRI scan is able to quantify the amount of time taken for blood to reach an area of the brain. | 1 hour |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05528666 -
Risk Perception in Multiple Sclerosis
|
||
Completed |
NCT03608527 -
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
|
N/A | |
Recruiting |
NCT05532943 -
Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis
|
Phase 1/Phase 2 | |
Completed |
NCT02486640 -
Evaluation of Potential Predictors of Adherence by Investigating a Representative Cohort of Multiple Sclerosis (MS) Patients in Germany Treated With Betaferon
|
||
Completed |
NCT01324232 -
Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis
|
Phase 2 | |
Completed |
NCT04546698 -
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis
|
||
Active, not recruiting |
NCT04380220 -
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
|
||
Completed |
NCT02835677 -
Integrating Caregiver Support Into MS Care
|
N/A | |
Completed |
NCT03686826 -
Feasibility and Reliability of Multimodal Evoked Potentials
|
||
Recruiting |
NCT05964829 -
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
|
N/A | |
Withdrawn |
NCT06021561 -
Orofacial Pain in Multiple Sclerosis
|
||
Completed |
NCT03653585 -
Cortical Lesions in Patients With Multiple Sclerosis
|
||
Recruiting |
NCT04798651 -
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
|
N/A | |
Active, not recruiting |
NCT05054140 -
Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
|
Phase 2 | |
Completed |
NCT05447143 -
Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
|
N/A | |
Recruiting |
NCT06195644 -
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
|
Phase 1 | |
Completed |
NCT04147052 -
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
|
N/A | |
Completed |
NCT03591809 -
Combined Exercise Training in Patients With Multiple Sclerosis
|
N/A | |
Completed |
NCT03594357 -
Cognitive Functions in Patients With Multiple Sclerosis
|
||
Completed |
NCT02845635 -
MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis
|