Multiple Sclerosis Clinical Trial
Official title:
Psychometric Properties of Mobility, Beyond Walking Speed, in Multiple Sclerosis: a Multi-center Study.
Current study will investigate the quality (psychometric properties) and clinical utility of
several mobility measures, according to disability level. Therefore, several aspects will be
inquired:
- Was there an effect of rehabilitation
- Is the measure able to detect change over time? And thus the change exceed measurement
error and is it clinically important (responsiveness)
- Does the measure assess what it claims to measure (validity)
- Is the measure able to differentiate all performances of the patients, inclusively the
very good and very bad performances (floor and ceiling effects)
- Does the measure gives similar results under consistent test conditions on another
testing day (reliability) Worldwide, theoretical approaches to physical therapy and
rehabilitation in Multiple Sclerosis often appear significantly different. Since the
present research protocol will be performed at different centers across European
countries (and US sites), this multi-center study can additionally be applied for
mapping the volume and content of rehabilitation, as well as the differential impact of
diverse rehabilitation approaches and training volume on mobility, for several
disability levels.
Some health-economic analyses will be performed to examine what the approximate cost of
rehabilitation compared to effects is and what drivers of costs are (setting, equipment,
staff).
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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