Respiratory Function and Walking Capacity in Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

Respiratory Function and Walking Capacity in Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01774201
• Other study ID #: OLL-260361
• Status: Completed
• Phase: N/A
• First received: January 18, 2013
• Last updated: January 16, 2017
• Start date: September 2012
• Est. completion date: December 2014

Study information

• Verified date: January 2017
• Source: Region Örebro County
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.

The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

Description:

Presented above.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 50
• Est. completion date: December 2014
• Est. primary completion date: December 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval = 3.0 - = 7.0.

• Participants must understand verbal and written information and must be relapse free = 3 months prior to inclusion.

Exclusion Criteria:

• Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.

Related Conditions & MeSH terms

• Difficulty Walking
• Mobility Limitation
• Multiple Sclerosis
• Respiration Disorders
• Respiratory; Disorder, Functional, Impaired
• Sclerosis

Intervention

Other:
• Breathing exercises
Breathing exercises with positive expiratory pressure.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Region Örebro County	Örebro County Council

References & Publications (2)

Nilsagård Y, Westerdahl E, Wittrin A, Gunnarsson M. Walking Distance as a Predictor of Falls in People With Multiple Sclerosis. Physiother Res Int. 2016 Jun;21(2):102-8. doi: 10.1002/pri.1625. — View Citation

Westerdahl E, Wittrin A, Kånåhols M, Gunnarsson M, Nilsagård Y. Deep breathing exercises with positive expiratory pressure in patients with multiple sclerosis - a randomized controlled trial. Clin Respir J. 2016 Nov;10(6):698-706. doi: 10.1111/crj.12272. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Respiratory muscle strength	Maximum expiratory pressure	Two months