A Pilot Study of Lithium in Progressive Multiple Sclerosis

Status Completed

Clinical Trial Summary

The purpose of this study is to determine whether lithium carbonate is safe, well-tolerated, and effective at treating progressive forms of multiple sclerosis.

Clinical Trial Description

In progressive multiple sclerosis (MS), patients experience worsening disability through a combination of inflammatory and neuro-degenerative processes. To test whether low-dose lithium carbonate ameliorates disability accumulation in progressive MS, patients with progressive MS were randomly assigned to take lithium in either the first or second year of a two-year trial. The trial was designed as a cross-over study to maximize exposure to lithium to for two reasons: 1) To increase the number of persons with MS exposed to lithium for purposes of assessing safety and tolerance; and 2) To increase the power to detect changes in the primary radiological outcome (change in brain volume) and also in secondary clinical outcomes (disability, mood, fatigue, cognition). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01259388
Study type	Interventional
Source	VA Office of Research and Development
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	May 2011
Completion date	December 2015

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