Pharmacogenomics of Drug Safety in Multiple Sclerosis

Status Recruiting

Clinical Trial Summary

To investigate whether genotypic differences can be identified between MS patients developing 'liver injury' (defined as ALT levels five times the upper normal limit and above) compared to those not developing liver injury after exposure to beta-interferon for MS.

Clinical Trial Description

PURPOSE: To investigate whether genotypic differences can be identified between MS patients who develop liver injury compared to those who do not develop injury in response to beta-interferon therapy. OBJECTIVE: To determine whether elevated liver enzyme tests (ALT > 5 times the upper limit of normal) in response to beta-interferon therapy in MS patients is associated with genetic polymorphisms. METHOD OF RECRUITMENT: Patients will be identified through a clinic database and chart reviews. An introductory letter will be mailed to potential participants, inviting them to volunteer. A follow-up phone call will be made to determine interest and consent into study. PROCEDURES: Saliva will be collected for genetic analyses and a questionnaire will be administered ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01118130
Study type	Observational
Source	University of British Columbia
Contact	Bruce Carleton, PharmD
Phone	604-875-2179
Email	bcarleton@popi.ubc.ca
Status	Recruiting
Phase
Start date	June 2010
Completion date	May 2025

View Details

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