Multiple Sclerosis Clinical Trial
Official title:
Longitudinal (Weekly) Follow-up of Active Plaques in Multiple Sclerosis With 3 Teslas Multi-modality MRI Using Diffusion, Perfusion, Venography and Proton Spectroscopy
It is difficult to determinate prognostic criteria of Multiple Sclerosis with conventional
MRI insofar as physiopathology is not well-known: the precise sequences of events leading to
plaque formation and axonal injury are still not completely understood.
Some elements involved in plaque formation can be studied thanks to MR techniques
(cerebrospinal fluid and periveinular spaces, neuronal injury, microglia, and cerebral
microcirculation's dysfunction).
This study aims at giving a better understanding of MS plaques' physiopathology, using data
from modern MRI through a longitudinal followed up with weakly MR 3T examination.
The objective of this work are:
- study weakly development of the active MS plaque with multimodal MRI parameters using
advanced MRI techniques: Veinography/3D FLAIR, Diffusion (CDA), Perfusion (CBV, CBF,
MTT) MR Spectroscopy (NAA, myo-inositol, choline, lactate…) and enhanced 3DT1
sequences.
- define prognostic markers of MS aggressiveness ("black holes")
- Study development of MS plaque around venous structures.
;
Intervention Model: Single Group Assignment, Masking: Open Label
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