Testosterone Treatment for Multiple Sclerosis

Status Completed

Clinical Trial Summary

Since men are less likely to develop multiple sclerosis, the hypothesis was that testosterone might be protective in MS. Men with MS for followed untreated for 6 months, followed by a 12 month treatment period with Androgel.

Clinical Trial Description

Background: Men are less susceptible to many autoimmune diseases including multiple sclerosis (MS). Possible causes for this include sex hormones and/or sex chromosome effects. Testosterone treatment ameliorates experimental allergic encephalomyelitis (EAE), an animal model of MS, but the effect of testosterone supplementation on men with MS is not known.

Design, Setting and Participants: Ten men with relapsing remitting MS were studied using a crossover design whereby each patient served as his own control. There was a six-month pretreatment period followed by a twelve month period of daily treatment with 100mg of testosterone gel.

Main Outcome Measures: Brain atrophy and Cognitive testing ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00405353
Study type	Interventional
Source	University of California, Los Angeles
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	April 2002
Completion date	March 2007

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