Novel Imaging Markers in SPMS

Status Completed

Clinical Trial Summary

This pilot study takes the innovative approach of using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle enhanced MRI to measure activity of the innate immune system within MS lesions. Activity of innate immunity has been hypothesized as one of the critical pathologic processes underpinning neurologic worsening in progressive MS. As such, in the short term this project proposes to investigate USPIO uptake in SPMS lesions as a promising in vivo imaging biomarker for chronic-active lesions, as distinguished from chronic-inactive lesions.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Multiple Sclerosis
Multiple Sclerosis, Chronic Progressive
Multiple Sclerosis, Secondary Progressive
Neoplasm Metastasis
Sclerosis
Secondary Progressive Multiple Sclerosis

Clinical Trial Details

NCT number	NCT05357833
Study type	Interventional
Source	University of Utah
Contact
Status	Completed
Phase	Early Phase 1
Start date	June 1, 2022
Completion date	September 1, 2023

View Details

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