Multiple Sclerosis Clinical Trial
Official title:
The French Multiple Sclerosis Registry
OFSEP is an observational cohort of Multiple Sclerosis (MS) and related disorders set up in
France. It aims to provide a major epidemiological tool on MS for the scientific community
in France and abroad. This tool must help to answer a large number of questions concerning
the causes and mechanisms of MS, the prognostic factors of disease progression, the
effectiveness and safety of therapeutic drugs, the impact of the disease on patients and
society, etc.
In December 2015, it has already included more than 54.000 patients. To achieve this goal,
OFSEP's objectives are
- To maintain and develop the French cohort of patients suffering from MS or related
diseases and syndromes. This means collecting standardized socio-demographic and
clinical data as part of the routine medical follow-up of patients already in the
cohort and recruitment of new patients.
- To supplement the existing clinical data with standardized and quality biological
samples and MRI scans.
- To improve the previous data with medical/administrative data from the health insurance
fund databases in particular, in order to get more information on comorbidity,
treatment protocols and the medico-economic aspects of this disease.
- To use OFSEP infrastructures to facilitate the implementation of specific studies
requiring the collection of additional data or specific patient monitoring processes.
- To ensure the availability of these data and samples to researchers, health care
authorities and industrial players to enable analysis and thus provide answers to
research questions or public health issues. This availability is only possible after
scientific and regulatory evaluation of the request.
- To provide regular descriptions of the patient population in the cohort to offer
statistics, targets and up-to-date information on this disease and thus enable a better
approach to the personal, professional and social impacts of the illness, the effects
of basic treatments and the requirements related to the follow-up of this disease in
France.
- To conduct specific studies on the entire population of patients in the cohort (parent
cohort) or on patient sub-groups with specific characteristics (nested cohorts). Four
nested cohorts have been defined: patients with radiologically isolated syndromes,
patients with clinically isolated syndromes, patients with primary progressive courses
of the disease and patients with neuromyelitis optica (Devic's syndrome) spectrum
disorders.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05528666 -
Risk Perception in Multiple Sclerosis
|
||
| Completed |
NCT03608527 -
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT05532943 -
Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis
|
Phase 1/Phase 2 | |
| Completed |
NCT02486640 -
Evaluation of Potential Predictors of Adherence by Investigating a Representative Cohort of Multiple Sclerosis (MS) Patients in Germany Treated With Betaferon
|
||
| Completed |
NCT01324232 -
Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis
|
Phase 2 | |
| Completed |
NCT04546698 -
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis
|
||
| Active, not recruiting |
NCT04380220 -
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
|
||
| Completed |
NCT02835677 -
Integrating Caregiver Support Into MS Care
|
N/A | |
| Completed |
NCT03686826 -
Feasibility and Reliability of Multimodal Evoked Potentials
|
||
| Recruiting |
NCT05964829 -
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
|
N/A | |
| Withdrawn |
NCT06021561 -
Orofacial Pain in Multiple Sclerosis
|
||
| Completed |
NCT03653585 -
Cortical Lesions in Patients With Multiple Sclerosis
|
||
| Recruiting |
NCT04798651 -
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
|
N/A | |
| Active, not recruiting |
NCT05054140 -
Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
|
Phase 2 | |
| Completed |
NCT05447143 -
Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT06195644 -
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
|
Phase 1 | |
| Completed |
NCT04147052 -
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
|
N/A | |
| Completed |
NCT03591809 -
Combined Exercise Training in Patients With Multiple Sclerosis
|
N/A | |
| Completed |
NCT03594357 -
Cognitive Functions in Patients With Multiple Sclerosis
|
||
| Completed |
NCT03269175 -
BENEFIT 15 Long-term Follow-up Study of the BENEFIT and BENEFIT Follow-up Studies
|
Phase 4 |