Multiple Sclerosis (MS) Clinical Trial
Official title:
Effect of Vitamin D Replacement on Immune Function and Cognition in MS Patients
Assessing the immune activation in MS patients deficient in Vitamin D and whether Vitamin D
supplementation reverse the immune activation
Evaluating whether Vitamin D deficiency result in lower cognitive performance in MS patients
and the effect of Vitamin D supplementation on reversing the cognitive impairment?
We will compare the immune responses in patients with Vitamin D deficiency (serum level
<20ng/ml) to those of patients with normal Vitamin D (serum level >35 ng/ml). We will focus
on proliferation and cytokine production to myelin basic protein (MBP) and myelin
oligodendrocyte glycoprotein (MOG) peptides and on the percentage of Th1 (IFN gamma producing
cells) and Th17 (IL-17 producing cells) during in vitro polarization assays. Our hypothesis
is that patients with low Vitamin D have increase proliferation to MBP and MOG and increased
production of pro-inflammatory cytokines (IFN gamma and IL-17) and that Vitamin D
supplementation will decrease this pro-inflammatory profile.
We will measure cognitive performance in patients with Vitamin D deficiency (serum level
<20ng/ml) compared to those of patients with normal Vitamin D (serum level >35 ng/ml) after
adjusting for educational levels and disease duration. We hypothesize that low Vitamin D has
a negative effect on cognitive performance and that Vitamin D supplementation will improve
cognitive function.
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