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TPE in Septic Patients and Influence on Organ Failure — TPEMOF  

Multiple Organ Failure Clinical Trial

Official title:
"Analyses on the Effectiveness and Technical Optimization of Therapeutic Plasma Exchange for Patients With Septic Shock, With Special Emphasis on Influencing the Kidney, Liver and Nervous System Through the Extracorporeal Therapy"

Clinical Trial Summary

Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study focusing on the organ functions of the patients.

Clinical Trial Description

Therapeutic plasma exchange (TPE) should used for patients with septic shock in a controlled, prospective study.

Investigators will study three groups:

1. untreated control group;

2. TPE group, plasma separation carried out by filtration;

3. TPE group, plasma separation carried out by centrifugation.

All treated patients should treated two (minimal) to five times by TPE, depending on the need of norephinephrine for the therapy. For each session 40 ml/kg body weight plasma should be exchange. Fluid resuscitation will be done with fresh frozen plasma. The study will focusing on the organ functions of the patients, especially liver-, kidney- and nervous function and also displayed in the SOFA score on study days 3 and 7. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02906345
Study type Interventional
Source University of Rostock
Contact Martin Sauer, MD
Phone 493814946409
Email martin.sauer@uni-rostock.de
Status Recruiting
Phase N/A
Start date September 2016
Completion date August 2022
View Details
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