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Clinical Trial Summary

This Phase II hybrid decentralized trial will examine the effect of daratumumab-based quadruplet induction therapy administered at an attenuated schedule in subjects with newly diagnosed multiple myeloma (NDMM) who are eligible for standard-of-care autologous stem cell transplantation (ASCT). Daratumumab, lenalidomide, bortezomib, and dexamethasone (Dara-RVd) have recently become a standard induction regimen for patients with NDMM who are eligible for ASCT in the United States. As implemented in clinical trials, Dara-RVd involves twice weekly bortezomib administration, which is inconvenient for patients and may result in increased rates of limiting toxicity, such as peripheral neuropathy. Adoption of alternate schedules involving once-weekly bortezomib is common in real-world practice, however a paucity of prospective data supporting this practice exists. This study examines the efficacy of an attenuated Dara-RVd schedule involving once-weekly bortezomib dosing.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06348147
Study type Interventional
Source UNC Lineberger Comprehensive Cancer Center
Contact Ralph L Dessieu
Phone 919-966-3066
Email Ralph-Lyne_Dessieu@med.unc.edu
Status Not yet recruiting
Phase Phase 2
Start date August 2024
Completion date August 2028

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