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COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide — COMMANDER  

Multiple Myeloma Clinical Trial

Official title:
Phase Ib/II Trial Of Iberdomide-Combinations In Patients With Positive Minimal Residual Disease (>10-5) After Autologous Hematopoietic Cell Transplantation In The Upfront Management Of Patients With Multiple Myeloma

Clinical Trial Summary

Similar to the paradigm established in other hematologic malignancies that are considered curable, the achievement of MRD(-) status is necessary for long term disease control in MM. The fact that the majority of patients remain MRD (+) after induction therapy and AHCT points to the opportunity to deploy novel agents with complementary mechanism of action and favorable toxicity profile to reach and maintain MRD (-) status. Given its favorable toxicity profile, the convenience of oral administration, and compelling single agent activity even in heavily pretreated MM, iberdomide is likely amenable to long term therapy in patients with high-risk of relapse/progression identified by the persistence of MRD(+). The investigators intend to develop combination(s) of iberdomide with other agents with complementary mechanism of action in the consolidation setting post AHCT in order to achieve and sustain MRD (-).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05434689
Study type Interventional
Source University of Alabama at Birmingham
Contact Pamela Hardwick, RN
Phone 205-975-5387
Email pamdixon@uab.edu
Status Recruiting
Phase Phase 1/Phase 2
Start date January 18, 2023
Completion date October 2026
View Details
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